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Referencia número: HY-P991143

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Biologically Validated

Ixotatug

(Synonyms: TORL-1-23 Antibody)

Revisión del cliente

Based on 1 Customer Validation

Ixotatug (TORL-1-23 Antibody) is a monoclonal antibody targeting claudin-6 (CLDN6) that serves as the antibody component of the ADC drug Ixotatug vedotin (TORL-1-23). Ixotatug is applicable to research related to various cancers including ovarian cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99%
No. CAS: 3018936-99-4
Peso molecular:145.032 kDa

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ixotatug Chemical Structure

No. CAS: 3018936-99-4

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Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Verified Bioactivity
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target^[1]

Claudin-6

In Vivo

Ixotatug (TORL-1-23 Antibody) serves as the antibody component of the ADC drug Ixotatug vedotin (TORL-1-23). Ixotatug vedotin selectively binds to tumor tissues with high CLDN6 expression, elicits partial anti-tumor responses in CLDN6-positive solid tumors of the ovary, testis and endometrium. When combined with Bevacizumab (HY-P9906), it achieves a 96% disease control rate in both platinum-resistant and platinum-sensitive subgroups of CLDN6-positive recurrent ovarian tumors, and exhibits durable anti-tumor effects^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

9074 [NCBI]

Accession

P56747

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-kappa

Aplicación

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Claudin-6/CLDN6 Protein-VLP, Human (HEK293, solution, HY-P77899) can bind Ixotatug. The EC₅₀ for this effect is 602 ng/mL.

Chemical Information

No. CAS 3018936-99-4
Appearance Liquid
Peso molecular 145.032 kDa
Color Colorless to light yellow
SMILES

N/A
Synonyms

TORL-1-23 Antibody
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (257 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Lee J Y, et al. 14oP Preliminary safety and efficacy of ixotatug vedotin (TORL-1-23), a Claudin 6-targeted ADC, in combination with bevacizumab in recurrent ovarian cancer. Abstract, 2026, 11(Suppl 6): 108187.

[2]. Konecny G E, et al. Initial results of dose finding in a first-in-human phase 1 study of a novel Claudin 6 (CLDN6) targeted antibody drug conjugate (ADC) TORL-1-23 in patients with advanced solid tumors. Journal of Clinical Oncology, 2023, 41(16_suppl): 3082.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Biological Activity
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Ixotatug

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Antibody Inhibitor Library

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Ixotatug Related Classifications

HY-P991143 Related Classifications