JQKD82
JQKD82 (JADA82) is a cell-permeable and selective KDM5 inhibitor. JQKD82 increases H3K4me3 and can be used for the research of multiple myeloma.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form that retains the same biological activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2410512-38-6
- Fòrmula: C27H40N4O5
- Peso molecular:500.63
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Other In-stock Forms of JQKD82
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-15648B
GSK-J4JMJD3/UTX Inhibitor -
HY-12304
IOX12OG Oxygenases Inhibitor -
HY-13953
JIB-04Histone Demethylase Inhibitor -
HY-18632
GSK2879552LSD1 Inhibitor -
HY-100421
CPI-455KDM5 Inhibitor -
HY-15648
GSK-J1JMJD3/KDM6B Inhibitor -
HY-12725
ML324JMJD2 Inhibitor -
HY-15648F
GSK-J4 hydrochlorideJMJD3/UTX Inhibitor -
HY-12635
SP2509LSD1 Antagonist -
HY-101799
NCGC00244536KDM4B Inhibitor -
HY-116761
GSK467KDM5B Inhibitor -
HY-107573
KDM2/7-IN-1KDM2/7 Inhibitor
Actividad biológica
Descripciòn
IC50 & Target
|
KDM5 |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MM1.S | EC50 |
0.42 μM
Compound: 48
|
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability
Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability
|
[PMID: 34555614] |
In Vitro
JQKD82 (0.3 μM; 24 hours) causes an increase in the global H3K4me3 level of MM.1S cells[1].
JQKD82 (0.1-10 μM; day 1-day 5) inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 is potent at eliciting growth suppression in MM.1S cells (IC50=0.42 μM)[1].
JQKD82 (1 μM; 24 hours) induces G1 cell-cycle arrest by 48 hours in MM.1S and MOLP-8 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
JQKD82 displays an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Six-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (bearing MOLP-8 TurboGFP-Luc cells)[1]
-
Dosage:50 mg/kg, 75 mg/kg
-
Administration:i.p.; twice a day for 3 weeks
-
Result:Significantly reduced tumor burden.
Chemical Information
-
No. CAS 2410512-38-6
-
Peso molecular 500.63
-
Fòrmula C27H40N4O5
-
SMILES
O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OC2=CC=C(C=C2OC(C)C)OC(C)C
-
Synonyms
JADA82; PCK82
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JQKD82 Related Classifications
HY-138691 Related Classifications
Powered by Bioz