JMX0293
JMX0293 is an O-alkylamino-tethered salicylamide derivative compound. JMX0293 maintains good potency against MDA-MB-231 cell line (IC50 = 3.38 μM) while exhibiting very low toxicity against human non-tumorigenic breast epithelial cell line MCF-10A (IC50> 60 μM). JMX0293 inhibits STAT3 phosphorylation and contribute to apoptosis in TNBC MDA-MB-231 cells. JMX0293 significantly suppresses MDA-MB-231 xenograft tumor growth in vivo without significant toxicity.
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- No. CAS: 3033232-87-7
- Fòrmula: C25H30Cl2N4O7
- Peso molecular:569.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
>60 μM
Compound: 9a; JMX0293
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Cytotoxicity against human MCF-10A cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells incubated for 72 hrs by MTT assay
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[PMID: 35334447] |
| MCF7 | IC50 |
9.05 μM
Compound: 9a; JMX0293
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 35334447] |
| MDA-MB-231 | IC50 |
3.38 μM
Compound: 9a; JMX0293
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 35334447] |
| MDA-MB-468 | IC50 |
18.28 μM
Compound: 9a; JMX0293
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 35334447] |
| T47D | IC50 |
8.92 μM
Compound: 9a; JMX0293
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Antiproliferative activity against human T47D cells assessed as inhibition of cell growth incubated fro 72 hrs by MTT assay
Antiproliferative activity against human T47D cells assessed as inhibition of cell growth incubated fro 72 hrs by MTT assay
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[PMID: 35334447] |
Chemical Information
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No. CAS 3033232-87-7
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Peso molecular 569.43
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Fòrmula C25H30Cl2N4O7
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SMILES
CC([C@H](NC(C1=C(C=CC(Cl)=C1)OCCNC(OC(C)(C)C)=O)=O)C(NC2=C(C=C(C=C2)[N+]([O-])=O)Cl)=O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JMX0293 Related Classifications
HY-144638 Related Classifications
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