JPC-3210
JPC-3210 is an orally active aminomethylphenol. JPC-3210 exhibits anti-malarial activity with a mean IC50 ranging from 2.5 to 19 nM. JPC-3210 works by inhibiting the hemoglobin digestion pathway and promoting regulators of protein translation. JPC-3210 can inhibit CYP2D6 and CYP3A4 isozymes. JPC-3210 suppresses P. berghei infection in mice model. JPC-3210 possesses prophylactic protection in vivo. JPC-3210 can be studied in research on malaria prevention.
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- No. CAS: 1609655-35-7
- Fòrmula: C21H26F4N2O
- Peso molecular:398.44
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Chemical Information
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No. CAS 1609655-35-7
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Peso molecular 398.44
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Fòrmula C21H26F4N2O
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SMILES
OC1=C(C2=CC(F)=C(C(F)(F)F)N=C2)C=C(C(C)(C)C)C=C1CNC(C)(C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Birrell, G. W., et al., (2020). Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum. Molecular & cellular proteomics : MCP, 19(2), 308-325. [Content Brief]
[2]. Birrell, G. W., et al., (2018). Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrobial agents and chemotherapy, 62(4), e01335-17. [Content Brief]
[3]. Chavchich, M., et al., (2016). Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrobial agents and chemotherapy, 60(5), 3115-3118. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JPC-3210 Related Classifications
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