KL044
Based on 2 publication(s) in Google Scholar
KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.50%
- No. CAS: 1801856-93-8
- Fòrmula: C21H14ClN3O
- Peso molecular:359.81
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) KL044
More
Actividad biológica
pEC50: 7.32[1]
KL044 (0-3.7 μM; 8 h) effectively stabilizes the CRY1-LUC fusion protein without affecting the stability of LUC in the HEK293 stable cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1801856-93-8
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Appearance Solid
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Peso molecular 359.81
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Fòrmula C21H14ClN3O
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Color Off-white to gray
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SMILES
O=C(CN1C2=C(C=CC=C2)C3=C1C=CC=C3)NC4=C(C=CC=C4Cl)C#N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Toxicology
Circadian PER2 promotes T-2 toxin-induced immunosenescence by activating the hippo/MST1 signaling in macrophages. [Abstract]2026 May 14:154501. PMID: 42140474 -
J Proteome Res
Isoglutaminyl Cyclase Overexpression Enhances KYSE30 Cancer Cell Proliferation and Migration via the MAPK Signaling Pathway. [Abstract]2024 May 3;23(5):1859-1870. PMID: 38655723
Solvente y solubilidad
DMSO : 100 mg/mL (277.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7792 mL | 13.8962 mL | 27.7924 mL | 69.4811 mL |
| 5 mM | 0.5558 mL | 2.7792 mL | 5.5585 mL | 13.8962 mL | |
| 10 mM | 0.2779 mL | 1.3896 mL | 2.7792 mL | 6.9481 mL | |
| 15 mM | 0.1853 mL | 0.9264 mL | 1.8528 mL | 4.6321 mL | |
| 20 mM | 0.1390 mL | 0.6948 mL | 1.3896 mL | 3.4741 mL | |
| 25 mM | 0.1112 mL | 0.5558 mL | 1.1117 mL | 2.7792 mL | |
| 30 mM | 0.0926 mL | 0.4632 mL | 0.9264 mL | 2.3160 mL | |
| 40 mM | 0.0695 mL | 0.3474 mL | 0.6948 mL | 1.7370 mL | |
| 50 mM | 0.0556 mL | 0.2779 mL | 0.5558 mL | 1.3896 mL | |
| 60 mM | 0.0463 mL | 0.2316 mL | 0.4632 mL | 1.1580 mL | |
| 80 mM | 0.0347 mL | 0.1737 mL | 0.3474 mL | 0.8685 mL | |
| 100 mM | 0.0278 mL | 0.1390 mL | 0.2779 mL | 0.6948 mL |
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