LB42908
LB42908 is a potent, selective and orally active farnesyltransferase inhibitor. LB42908 inhibits farnesylation of H-Ras, K-Ras with IC50 values of 0.9 nM, 2.4 nM for H-Ras, K-Ras, respectively. LB42908 shows antiproliferative activity. LB42908 shows antitumor activity.
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- No. CAS: 226927-89-5
- Fòrmula: C32H31N5O3
- Peso molecular:533.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
IC50: 0.9 nM (H-Ras); 2.4 nM (K-Ras)[1]
LB42908 shows antiproliferative activity with GI50s of 4.5, 17.6, 1.2, 0.56, 0.45 nM for HT29, HCT116, A549, EJ, T24 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 226927-89-5
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Peso molecular 533.62
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Fòrmula C32H31N5O3
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SMILES
O=C(C1=CN(CC2=CN=CN2CC3=CC=C(OCO4)C4=C3)C=C1C5=C6C=CC=CC6=CC=C5)N7CCN(C)CC7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LB42908 Related Classifications
HY-120763 Related Classifications
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