LCA-H10
LCA-H10 is a bile acid-peptide lipid nanoparticle additive and endosomal escape inducer. LCA-H10 acts through a histidine peptide-mediated proton sponge effect. LCA-H10 interacts with siRNA, enabling encapsulation of siRNA in low-ionizable lipid lipid nanoparticles. LCA-H10 enhances siRNA-mediated GFP gene silencing. LCA-H10 can be used for research on prostate cancer.
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- Fòrmula: C84H110N30O13
- Peso molecular:1747.97
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
Descripciòn
In Vitro
LCA-H10 (0.9 mol%; 4°C overnight) achieves 83.7% siRNA encapsulation efficiency, a zeta potential of -16.0 mV, a pKa of 6.3, and an AFM height of 16.4 nm in LiLNP-LH[1].
LCA-H10 (2.0-10.0 × 1010 particles/mL; incubated at 37°C for 1 h) exhibits pH-dependent hemolysis in LiLNP-LH, with a hemolysis rate of 16.1% at pH 6.0 and no hemolysis at pH 7.4[1].
LCA-H10 (24 h) exhibits good biocompatibility in PC3 cells in LiLNP-LH[1].
LCA-H10 (5-43 h) silences GFP in PC3-GFP cells in LiLNP-LH, with an IC50 value of 216.9 nM for ALC-0315-based LNPs and an IC50 value of 352.6 nM for SM102-based LNPs[1].
LCA-H10 (37°C incubation for 4 h) promotes endosomal membrane destabilization in LiLNP-LH and the release of Calcein (HY-D0040) into the nucleus of PC3 cells, with a nuclear fluorescence intensity of 21.0[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 1747.97
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Fòrmula C84H110N30O13
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Sequence
LCA-His-His-His-His-His-His-His-His-His-His
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Sequence Shortening
LCA-HHHHHHHHHH
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Topics Lipid Nanoparticles: Key Nucleic Acid Delivery Vectors
Lipid nanoparticles (LNPs) are the most clinically advanced non-viral delivery systems for nucleic acid therapeutics and enable the in vivo delivery of mRNA, siRNA, and other genetic cargos.
2026-06-18
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LCA-H10 Related Classifications
HY-P11614 Related Classifications
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