country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-P992534

Copy Link Print Information

LEVI-04

LEVI-04 is a p75NTR-Fc fusion protein. LEVI-04 blocks and clears neurotrophins, binding excess NGF to block NGF activity, and binds NT-3 with high affinity to inhibit NT-3 activity. LEVI-04 inhibits NT-3-mediated TrkC receptor signaling and supplements endogenous p75NTR. LEVI-04 can be used in research on osteoarthritis and knee osteoarthritis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEVI-04 Chemical Structure

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Species Reactivity
- IC₅₀ & Target
- Target
- Conjugated
- Aplicación
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Species Reactivity

Human

IC₅₀ & Target

^[1]

TrkC

Ver todos los productos específicos de isoformas Trk Receptor :

Target

NT-3

Conjugated

Unconjugated

Aplicación

ELISA, FACS, Functional assay

Chemical Information

SMILES

[LEVI-04]
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Fedotcheva TA, et al. Current State of the Neurotrophin-Based Pharmaceutics in the Treatment of Neurodegenerative Diseases and Neuroinflammation. Medical sciences (Basel, Switzerland). 2025 Dec 29;14(1):15. [Content Brief]

[2]. Conaghan P G, et al. OA04 A randomised controlled Phase II trial of LEVI-04, a novel neurotrophin-3 inhibitor, in knee osteoarthritis demonstrates substantially improved pain and function without deleterious effects on joint structure[J]. Rheumatology, 2025, 64(Supplement_3): keaf142. 004.

[3]. Conaghan P G, et al. LEVI-04, A NOVEL NEUROTROPHIN-3 INHIBITOR, SUBSTANTIALLY IMPROVES PAIN AND FUNCTION IN PEOPLE WITH KNEE OSTEOARTHRITIS: A RANDOMISED CONTROLLED PHASE II TRIAL[J]. Osteoarthritis and Cartilage, 2025, 33: S65-S66.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto