LS-106
LS-106 is an orally active and potent inhibitor against epidermal growth factor receptor (EGFR) . LS-106 exhibits antitumor activities both in vitro and in vivo. LS-106 inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, which is more potent than Osimertinib (HY-15772). LS-106 induces Apoptosis, suppresses cell proliferation of tumor cells harboring EGFR19del/T790M/C797S and leas to significant tumor regression in a C797S-mutant xenograft model.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C24H28BrClN5OP
- Peso molecular:548.84
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas EGFR
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Actividad biológica
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EGFR19del/T790M/C797S 2.4 nM (IC50) |
EGFRL858R/T790M/C797S 3.1 nM (IC50) |
EGFRL858R/T790M 7.3 nM (IC50) |
EGFR19del/T790M 74.1 nM (IC50) |
EGFRwt 151.5 nM (IC50) |
EGFR19del 402.9 nM (IC50) |
Chemical Information
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Peso molecular 548.84
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Fòrmula C24H28BrClN5OP
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SMILES
CP(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC(C)CC4)C(Br)=C3)=NC=C2Cl)(C)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LS-106 Related Classifications
HY-164490 Related Classifications
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