Lysostaphin
Based on 1 publication(s) in Google Scholar
Lysostaphin is an antistaphylococcal agent. Lysostaphin has activities of three enzymes namely, glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase.
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- No. CAS: 9011-93-2
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Lysostaphin
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Actividad biológica
Lysostaphin (16 μg/mL, 0-260 minutes) exerts its antibacterial effect by hydrolyzing the peptidoglycan cross-linkages of Staphylococcus aureus, weakening the mechanical strength of the cell wall and causing structural damage[3].
Product Information
Molecular weight: 27 kDa
Effective pH range: 5.0-8.0
Instructions
Can be dissolved in ddH2O at a concentration of 1 mg/mL. Fresh preparation is recommended. Or dissolve in buffer according to specific experimental references.
Notes
PCMB, PMSF, DTT, etc. have no obvious effect on enzyme activity at 1 mM. Ba2+, Mn2+, Ca2+, Mg2+ and EDTA show a certain degree of inhibitory effect on enzyme activity at a concentration of 1 mM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Systemic infection model in CF-1 mice induced by methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)[2]
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Dosage:1, 5, 25, 50 mg/kg
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Administration:Intravenous injection (i.v.), single high-dose administration: 25 mg/kg or 50 mg/kg intravenous injection, single dose; Once daily administration: 1 or 5 mg/kg, once daily for 3 days.
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Result:Cleared MSSA from the blood and organs of mice (5 mg/kg for 3 days). Cleared MSSA and MRSA from the kidneys, spleen, and liver (A higher single dose of 50 mg/kg). Improved effectiveness and allowed reduction of the lysostaphin dose to 1 mg/kg for MRSA infections (Combined with Oxacillin (HY-B0925A) or Vancomycin (HY-B0671)).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
3.4.24.75
≥1200 U/mg soild
One unit is defined as the amount of enzyme required to reduce the OD620 absorption value by 0.01 per minute at 37°C and pH 7.5
Chemical Information
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No. CAS 9011-93-2
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Appearance Solid
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Color White to off-white
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SMILES
[Lysostaphin]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
Lipolysis of host triacylglyceride-rich lipoproteins creates a toxic microenvironment for Staphylococcus aureus. [Abstract]2026 Jan 12:2026.01.12.699058. PMID: 41648463
Solvente y solubilidad
H2O : ≥ 1 mg/mL
* "≥" means soluble, but saturation unknown.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Jaspal K Kumar, et al. Lysostaphin: An Antistaphylococcal Agent. Appl Microbiol Biotechnol. 2008 Sep;80(4):555-61. [Content Brief]
[2]. Kokai-Kun JF, et al. Lysostaphin as a treatment for systemic Staphylococcus aureus infection in a mouse model. J Antimicrob Chemother. 2007 Nov;60(5):1051-9. [Content Brief]
[3]. Francius G, et al. Direct observation of Staphylococcus aureus cell wall digestion by lysostaphin. J Bacteriol. 2008 Dec;190(24):7904-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lysostaphin Related Classifications
HY-P2329 Related Classifications
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