MAC13772
Based on 1 publication(s) in Google Scholar
MAC13772 is a BioA inhibitor with an IC50 of 0.28 μM against E. coli and an IC50 of 0.269 μM against A. baumannii. MAC13772 inhibits bacterial growth by targeting the biotin biosynthesis pathway. MAC13772 can be used in studies related to bacterial infections.
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- Pureza: 99.33%
- No. CAS: 4871-40-3
- Fòrmula: C8H9N3O3S
- Peso molecular:227.24
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MAC13772
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Actividad biológica
MAC13772 inhibits the purified E. coli BioA enzyme with an IC50 of 0.28 μM[1].
MAC13772 inhibits purified A. baumannii BioA enzyme with an IC50 value of 0.269 μM[1].
MAC13772 inhibits the growth of E. coli BW25113 WT and A. baumannii ATCC 17978 WT in biotin-free minimal medium, with an MIC of 8 μg/mL for both strains, and this activity is reversible by biotin supplementation[1].
MAC13772 (0.01-100 μM; 20 days) inhibits the growth of Phaeodactylum tricornutum by targeting biotin synthesis, reduces the level of protein biotinylation, and exogenous biotin supplementation can partially restore its growth[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 4871-40-3
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Appearance Solid
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Peso molecular 227.24
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Fòrmula C8H9N3O3S
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Color Light yellow to yellow
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SMILES
O=C(NN)CSC1=CC=CC=C1[N+]([O-])=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Plant J
Decreasing protein biotinylation background in a diatom facilitates proximity labeling of the periplastidial compartment proteome. [Abstract]2025 Jun;122(5):e70259. PMID: 40489604
Solvente y solubilidad
DMSO : 17.86 mg/mL (78.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.79 mg/mL (7.88 mM); Clear solution
This protocol yields a clear solution of ≥ 1.79 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (17.9 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4006 mL | 22.0032 mL | 44.0063 mL | 110.0158 mL |
| 5 mM | 0.8801 mL | 4.4006 mL | 8.8013 mL | 22.0032 mL | |
| 10 mM | 0.4401 mL | 2.2003 mL | 4.4006 mL | 11.0016 mL | |
| 15 mM | 0.2934 mL | 1.4669 mL | 2.9338 mL | 7.3344 mL | |
| 20 mM | 0.2200 mL | 1.1002 mL | 2.2003 mL | 5.5008 mL | |
| 25 mM | 0.1760 mL | 0.8801 mL | 1.7603 mL | 4.4006 mL | |
| 30 mM | 0.1467 mL | 0.7334 mL | 1.4669 mL | 3.6672 mL | |
| 40 mM | 0.1100 mL | 0.5501 mL | 1.1002 mL | 2.7504 mL | |
| 50 mM | 0.0880 mL | 0.4401 mL | 0.8801 mL | 2.2003 mL | |
| 60 mM | 0.0733 mL | 0.3667 mL | 0.7334 mL | 1.8336 mL |
MAC13772 Related Classifications
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