Monarsen
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 864021-55-6
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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AChE |
Chemical Information
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No. CAS 864021-55-6
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SMILES
[Monarsen]
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Synonyms
EN101; ODN 7040; BL 7040
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Sequence
DNA, d(C-T-G-C-G-A-T-A-T-T-T-T-C-T-T-G-T-rAm-rCm-rCm)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Sussman JD, Argov Z, McKee D, Hazum E, Brawer S, Soreq H. Antisense treatment for myasthenia gravis: experience with monarsen. Ann N Y Acad Sci. 2008;1132:283-290. [Content Brief]
[2]. Evron T, Moyal-Segal LB, Lamm N, Geffen A, Soreq H. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegener Dis. 2005;2(1):16-27. [Content Brief]
[3]. Kehat R, Zemel E, Cuenca N, et al. A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress. Invest Ophthalmol Vis Sci. 2007;48(3):1290-1297. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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