MPI8
MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 856242-63-2
- Fòrmula: C32H48N4O7
- Peso molecular:600.75
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas Cathepsin
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Actividad biológica
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SARS-CoV‑2 Main Protease |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
70 μM
Compound: MPI8
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Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38608245] |
| Vero C1008 | CC50 |
>200 μM
Compound: 105
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CCK8 assay
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[PMID: 34798775] |
Chemical Information
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No. CAS 856242-63-2
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Peso molecular 600.75
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Fòrmula C32H48N4O7
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SMILES
O=C(N[C@H](C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC2CCCCC2)=O)[C@@H](C)OC(C)(C)C)OCC3=CC=CC=C3
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Synonyms
TG0205221
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Ma X R, et al. MPI8 is potent against SARS‐CoV‐2 by inhibiting dually and selectively the SARS‐CoV‐2 main protease and the host cathepsin L[J]. ChemMedChem, 2022, 17(1): e202100456. [Content Brief]
[2]. Yang S, et al. Synthesis, crystal structure, structure− activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor[J]. Journal of medicinal chemistry, 2006, 49(16): 4971-4980. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPI8 Related Classifications
HY-158763 Related Classifications
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