NCL1
NCL1 is a phenylcyclopropylamine (PCPA)-based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC50 values of 2.5 and 26 μM for LSD1 and LSD2, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1196119-03-5
- Fòrmula: C27H29N3O3
- Peso molecular:443.54
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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LSD1 2.5 ± 0.5 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
6 μM
Compound: 31
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Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 22975593] |
| HCT-116 | GI50 |
6 μM
Compound: NCL-1
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Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
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[PMID: 32931269] |
| HeLa | GI50 |
13 μM
Compound: 4; NCL1
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Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay
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10.1039/C4MD00330F |
| HeLa | GI50 |
6 μM
Compound: 31
|
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
|
[PMID: 22975593] |
| HeLa | GI50 |
6 μM
Compound: NCL-1
|
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 32931269] |
| KYSE-150 cell line | GI50 |
6 μM
Compound: 31
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Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay
Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay
|
[PMID: 22975593] |
| KYSE-150 cell line | GI50 |
6 μM
Compound: NCL-1
|
Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay
Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay
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[PMID: 32931269] |
| PC-3 | GI50 |
6 μM
Compound: 31
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Growth inhibition of human PC3 cells after 48 hrs by MTT assay
Growth inhibition of human PC3 cells after 48 hrs by MTT assay
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[PMID: 22975593] |
| PC-3 | GI50 |
6 μM
Compound: NCL-1
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Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay
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[PMID: 32931269] |
| SH-SY5Y | GI50 |
27 μM
Compound: 4; NCL1
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Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay
Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay
|
10.1039/C4MD00330F |
| SH-SY5Y | GI50 |
6 μM
Compound: 31
|
Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay
Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay
|
[PMID: 22975593] |
| SH-SY5Y | GI50 |
6 μM
Compound: NCL-1
|
Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay
Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay
|
[PMID: 32931269] |
Chemical Information
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No. CAS 1196119-03-5
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Peso molecular 443.54
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Fòrmula C27H29N3O3
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SMILES
O=C(N[C@H](C(NCC1=CC=CC=C1)=O)CCOC2=CC=CC(C3C(N)C3)=C2)C4=CC=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NCL1 Related Classifications
HY-12645 Related Classifications
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