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Referencia número: HY-12645

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NCL1

NCL1 is a phenylcyclopropylamine (PCPA)-based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC₅₀ values of 2.5 and 26 μM for LSD1 and LSD2, respectively.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1196119-03-5
Fòrmula: C₂₇H₂₉N₃O₃
Peso molecular:443.54

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NCL1 Chemical Structure

No. CAS: 1196119-03-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocolo (1)
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

LSD1

2.5 ± 0.5 μM (IC₅₀)

Ver todos los productos específicos de isoformas Histone Demethylase :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	6 μM Compound: 31	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 22975593]
HCT-116	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 32931269]
HeLa	GI₅₀	13 μM Compound: 4; NCL1	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay	10.1039/C4MD00330F
HeLa	GI₅₀	6 μM Compound: 31	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 22975593]
HeLa	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 32931269]
KYSE-150 cell line	GI₅₀	6 μM Compound: 31	Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay	[PMID: 22975593]
KYSE-150 cell line	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay	[PMID: 32931269]
PC-3	GI₅₀	6 μM Compound: 31	Growth inhibition of human PC3 cells after 48 hrs by MTT assay Growth inhibition of human PC3 cells after 48 hrs by MTT assay	[PMID: 22975593]
PC-3	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay	[PMID: 32931269]
SH-SY5Y	GI₅₀	27 μM Compound: 4; NCL1	Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay	10.1039/C4MD00330F
SH-SY5Y	GI₅₀	6 μM Compound: 31	Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 22975593]
SH-SY5Y	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 32931269]

Chemical Information

No. CAS 1196119-03-5
Peso molecular 443.54
Fòrmula C₂₇H₂₉N₃O₃
SMILES

O=C(N[C@H](C(NCC1=CC=CC=C1)=O)CCOC2=CC=CC(C3C(N)C3)=C2)C4=CC=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kakizawa T, et al. Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1193-5. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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