NSC697923
Based on 8 publication(s) in Google Scholar
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.90%
- No. CAS: 343351-67-7
- Fòrmula: C11H9NO5S
- Peso molecular:267.26
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Anti-Cancer Compound Library
HY-L025
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Covalent Screening Library
HY-L036
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Oxygen Sensing Compound Library
HY-L045
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Ubiquitination Compound Library
HY-L050
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Anti-Liver Cancer Compound Library
HY-L101
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Cell Death Library
HY-L162
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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Amino Acid Metabolism Compound Library
HY-L189
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Publications Citing Use of MedChemExpress (MCE) NSC697923
More- Autophagy. 2025 Aug 16. [Abstract]
- Redox Biol. 2025 Aug 20:86:103836. [Abstract]
- Research (Wash D C). 2025 Dec 23:8:1041. [Abstract]
- J Cell Physiol. 2025 Jan;240(1):e31459. [Abstract]
- Viruses. 2023 Feb 28;15(3):655. [Abstract]
- BMC Pulm Med. 2024 Oct 29;24(1):542. [Abstract]
- bioRxiv. 2026 May 29:2026.05.26.727520. [Abstract]
- bioRxiv. 2025 Dec 12.
Customer Validation & Images
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Cell Imaging/Staining
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WB
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IP
Actividad biológica
NSC697923 (0-5 μM; 24 hours) shows cytotoxic effect on NB cell lines[1].
NSC697923 (3 μM; 2 hours) can also induce apoptosis in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway[1].
NSC697923 induces apoptosis in p53 wild-type NB cell lines by promoting p53 nuclear translocation and activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Three MYCN-amplified cell lines: IMR32, NGP, NB19 and three MYCN-non-amplified cell lines: CHLA-255, SK-N-AS, and SH-SY5Y
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Concentration:0-5 μM
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Incubation Time:24 hours
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Result:Significantly reduced NB cells viability in a dose-dependent manner. Also induced cell death in the p53 non-functional cell line SK-N-AS and p53 partially functional cell line NB-19.
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Cell Line:p53 wild-type SH-SY5Y and IMR32 cells
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Concentration:3 μM
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Incubation Time:2 hours
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Result:Induced expression of p53-targeted gene p21 as well as the cleavage of caspase 3 in two p53 wild-type cell lines SH-SY5Y and IMR32.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5- to 6-week-old female athymic Ncr nude mice (orthotopic mouse model of NB; SH-SY5Y and NGP xenografts)[1]
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Dosage:5 mg/kg
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Administration:I.p.; daily for 10 days
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Result:Significant tumor regression in both SH-SY5Y and NGP xenografts.
Chemical Information
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No. CAS 343351-67-7
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Appearance Solid
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Peso molecular 267.26
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Fòrmula C11H9NO5S
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Color White to light yellow
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SMILES
O=S(C1=CC=C([N+]([O-])=O)O1)(C2=CC=C(C)C=C2)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
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Journal Impact Factor
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Most Recent
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Autophagy
Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice. [Abstract]2025 Aug 16. PMID: 40818063 -
Redox Biol
p53 promote oxidative stress, neuroinflammation and behavioral disorders via DDIT4-NF-κB signaling pathway. [Abstract]2025 Aug 20:86:103836. PMID: 40848509
NSC697923 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 20:86:103836. [Abstract]
NSC697923 (NSC) (2 mg/kg/d, i.p). DHE fluorescence intensity was higher in the CORT + Cur + NSC group, indicating increased ROS accumulation.
NSC697923 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 20:86:103836. [Abstract]
NSC697923 (NSC) (2 mg/kg/d, i.p). Western blot analysis showed increased p53, DDIT4, p-p65 and p65 protein levels in the CORT + Cur + NSC group compared to the CORT + Cur group.
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Research (Wash D C)
UBE2V1 Promotes Hepatocellular Carcinoma Progression by Forming a Positive Feedback Loop with HIF-1α. [Abstract]2025 Dec 23:8:1041. PMID: 41446875
NSC697923 purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 Dec 23:8:1041. [Abstract]
NSC697923 (3 and 4 μM). Assessment of the effect of UBC13 inhibition on VHL ubiquitination.
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J Cell Physiol
2025 Jan;240(1):e31459. PMID: 39373061 -
Viruses
Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses. [Abstract]2023 Feb 28;15(3):655. PMID: 36992362 -
BMC Pulm Med
2024 Oct 29;24(1):542. PMID: 39472837 -
bioRxiv
2026 May 29:2026.05.26.727520. PMID: 42244578 -
Solvente y solubilidad
DMSO : 100 mg/mL (374.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (18.71 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5(2):e1079. Published 2014 Feb 20. [Content Brief]
[2]. Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10(7):1718-1728. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7417 mL | 18.7084 mL | 37.4167 mL | 93.5419 mL |
| 5 mM | 0.7483 mL | 3.7417 mL | 7.4833 mL | 18.7084 mL | |
| 10 mM | 0.3742 mL | 1.8708 mL | 3.7417 mL | 9.3542 mL | |
| 15 mM | 0.2494 mL | 1.2472 mL | 2.4944 mL | 6.2361 mL | |
| 20 mM | 0.1871 mL | 0.9354 mL | 1.8708 mL | 4.6771 mL | |
| 25 mM | 0.1497 mL | 0.7483 mL | 1.4967 mL | 3.7417 mL | |
| 30 mM | 0.1247 mL | 0.6236 mL | 1.2472 mL | 3.1181 mL | |
| 40 mM | 0.0935 mL | 0.4677 mL | 0.9354 mL | 2.3385 mL | |
| 50 mM | 0.0748 mL | 0.3742 mL | 0.7483 mL | 1.8708 mL | |
| 60 mM | 0.0624 mL | 0.3118 mL | 0.6236 mL | 1.5590 mL | |
| 80 mM | 0.0468 mL | 0.2339 mL | 0.4677 mL | 1.1693 mL | |
| 100 mM | 0.0374 mL | 0.1871 mL | 0.3742 mL | 0.9354 mL |
NSC697923 Related Classifications
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