NW16
NW16 is an orally active inhibitor for STAT3 with Kd of 11.0 μM. NW16 arrests the cell cycle at S phase, induces apoptosis in HCT116, and inhibits the proliferation of cancer cell HCT116, A549, and B16 with IC50s of 0.28, 1.22, and 9.86 μM, respectively. NW16 induces the production of ROS, inhibits the PI3K/AKT signaling pathway, and thus exhibits antitumor efficacy in mouse model.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C18H12N2O5
- Peso molecular:336.30
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
STAT3 11.0 μM (Kd) |
Chemical Information
-
Peso molecular 336.30
-
Fòrmula C18H12N2O5
-
SMILES
N#C/C(C(NCCO)=O)=C\C1=CC2=C(O1)C(C3=CC=CC=C3C2=O)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NW16 Related Classifications
HY-169403 Related Classifications
Powered by Bioz