Ocankitug
Based on 1 Customer Validation
Ocankitug (CM-326) is a humanized IgG1κ antibody targeting thymic stromal lymphopoietin (TSLP). It can be used for research on type 2 inflammatory respiratory diseases, including moderate to severe asthma, chronic sinusitis with nasal polyps, etc.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : ≥99.0%
- No. CAS: 2803351-66-6
- Peso molecular:145.32 kDa
-
Almacenamiento:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
-
Help & FAQs
Actividad biológica
Descripciòn
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
|
IL7R |
In Vitro
Ocankitug binds to TSLP with high affinity, blocking its interaction with the receptor (TSLPR/IL-7Rα), thereby inhibiting the activation of downstream dendritic cells, Th2 cells, and eosinophils, and interfering with the type 2 inflammatory pathway at its source.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Q969D9-1
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
IgG1-kappa
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
-
Immobilized TSLP Protein, Human (HEK293, His, HY-P70818) can bind Ocankitug. The EC50 for this effect is 2.541 ng/mL.
Chemical Information
-
No. CAS 2803351-66-6
-
Appearance Liquid
-
Peso molecular 145.32 kDa
-
Color Colorless to light yellow
-
SMILES
[Ocankitug]
-
Synonyms
CM-326
-
Envío
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
-
Ficha de datos (230 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ocankitug Related Classifications
HY-P990933 Related Classifications
Powered by Bioz