Paltimatrectinib
Based on 1 Customer Validation
Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.95%
- No. CAS: 2353522-15-1
- Fòrmula: C20H15F5N6
- Peso molecular:434.37
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Immunology/Inflammation Compound Library
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Actividad biológica
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TrkA |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2353522-15-1
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Appearance Solid
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Peso molecular 434.37
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Fòrmula C20H15F5N6
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Color Off-white to yellow
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SMILES
FC(F)(C1=CN(N=C1)C2=C3N(C=CC(N4[C@](C5=C(C=CC(F)=C5)F)([H])CCC4)=N3)N=C2)F
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Synonyms
PBI-200; PPI-5278
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 25 mg/mL (57.55 mM; ultrasonic and warming and heat to 75°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3022 mL | 11.5109 mL | 23.0218 mL | 57.5546 mL |
| 5 mM | 0.4604 mL | 2.3022 mL | 4.6044 mL | 11.5109 mL | |
| 10 mM | 0.2302 mL | 1.1511 mL | 2.3022 mL | 5.7555 mL | |
| 15 mM | 0.1535 mL | 0.7674 mL | 1.5348 mL | 3.8370 mL | |
| 20 mM | 0.1151 mL | 0.5755 mL | 1.1511 mL | 2.8777 mL | |
| 25 mM | 0.0921 mL | 0.4604 mL | 0.9209 mL | 2.3022 mL | |
| 30 mM | 0.0767 mL | 0.3837 mL | 0.7674 mL | 1.9185 mL | |
| 40 mM | 0.0576 mL | 0.2878 mL | 0.5755 mL | 1.4389 mL | |
| 50 mM | 0.0460 mL | 0.2302 mL | 0.4604 mL | 1.1511 mL |
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