PD-166285
PD-166285 is a PKMYT1 inhibitor, with an IC50 value of 17 nM. PD166285 shows strong antiproliferative effects against CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM). PD166285 induces apoptosis and arrests CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle. PD166285 can be used for the research of PKMYT1-targeted therapies for CCNE1-amplified cancers.
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- No. CAS: 717094-37-6
- Fòrmula: C24H23Cl2N5O2
- Peso molecular:484.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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PKMYT1 17 nM (IC50) |
PD166285 (0.062-1 μM, 5 days) shows strong antiproliferative effects against CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM)[1].
PD166285 (14 days) inhibits colony formation of CCNE1-amplified OVCAR3 cells in a concentration-dependent manner (EC50 = 0.06 μM) and HCC1569 cells (EC50 = 0.16 μM)[1].
PD166285 (0.125-1 μM, 5 days) induces apoptosis and arrests CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CCNE1-amplified HCC1569 cells
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Concentration:0.125, 0.25, 0.5 μM
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Incubation Time:5 days
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Result:Arrested CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle.
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Cell Line:CCNE1-amplified HCC1569 cells
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Concentration:0.125, 0.25, 0.5, 1 μM
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Incubation Time:5 days
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Result:Induced apoptosis in CCNE1-amplified HCC1569 cells.
Chemical Information
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No. CAS 717094-37-6
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Peso molecular 484.38
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Fòrmula C24H23Cl2N5O2
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SMILES
ClC1=CC=CC(Cl)=C1C2=CC3=C(N=C(NC4=CC=C(OCCN(C)C)C=C4)N=C3)N(C)C2=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-166285 Related Classifications
HY-175819 Related Classifications
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