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Referencia número: HY-164521

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PMMB-187

PMMB-187 is a selective STAT3 inhibitor with an IC₅₀ value of 1.81 μM for MDA-MB-231 cells. PMMB-187 induces apoptosis (Apoptosis) in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity, nuclear translocation, and downstream target gene expression, while also reducing mitochondrial membrane potential, generating reactive oxygen species (ROS), and upregulating the expression levels of apoptosis-related proteins. PMMB-187 has potential applications in cancer research.

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No. CAS: 2162952-37-4
Fòrmula: C₂₇H₂₃BrN₂O₆S₂
Peso molecular:615.52

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PMMB-187 Chemical Structure

No. CAS: 2162952-37-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Stat-3

1.81 μM (IC₅₀)

Ver todos los productos específicos de isoformas STAT :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	86.9 μM Compound: 1-62	Cytotoxicity against human MCF-10A assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Cytotoxicity against human MCF-10A assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]
MCF7	IC₅₀	4.71 μM Compound: 126	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA	[PMID: 38458106]
MCF7	IC₅₀	4.71 μM Compound: 1-62	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]
MDA-MB-231	IC₅₀	1.81 μM Compound: 126	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA	[PMID: 38458106]
MDA-MB-231	IC₅₀	1.81 μM Compound: 1-62	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]
MDA-MB-231	IC₅₀	1.81 μM Compound: 35	Antiproliferative activity against human MDA-MB-231 cells Antiproliferative activity against human MDA-MB-231 cells	[PMID: 34170703]
MDA-MB-468	IC₅₀	2.99 μM Compound: 126	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT reagent based ELISA	[PMID: 38458106]
MDA-MB-468	IC₅₀	2.99 μM Compound: 1-62	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]

Chemical Information

No. CAS 2162952-37-4
Peso molecular 615.52
Fòrmula C₂₇H₂₃BrN₂O₆S₂
SMILES

O=C1C2=C(O)C=CC(O)=C2C(C=C1[C@@H](C/C=C(C)/C)OC(CSC3=NN=C(CC4=CC=C(C=C4)Br)S3)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Qiu HY, et al. Identification of new shikonin derivatives as STAT3 inhibitors. Biochem Pharmacol. 2017 Dec 15;146:74-86. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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PMMB-187

Ver todos los productos específicos de isoformas STAT

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PMMB-187 Related Classifications

HY-164521 Related Classifications