PROTAC ER Degrader-14
PROTAC ER Degrader-14 (compound 86) is a PTORAC-type Estrogen Receptor/ERR degrader.
(Pink: Estrogen Receptor/ERR ligand (HY-170341); Blue: Cereblon ligand (HY-168055); Black: linker (HY-30105)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2504911-73-1
- Fòrmula: C44H46FN5O5
- Peso molecular:743.86
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 2504911-73-1
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Peso molecular 743.86
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Fòrmula C44H46FN5O5
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SMILES
O=C1N([C@H](C(N2)=O)CCC2=O)CC3=C1C=CC(N4CCN(CC5CCN(C6=CC=C([C@H]7[C@@H](C8=CC=CC=C8)COC9=C7C=CC(O)=C9)C=C6F)CC5)CC4)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC ER Degrader-14 Related Classifications
HY-170340 Related Classifications
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