Puberulin
Puberulin is a coumarin compound and an orally effective analgesic. Puberulin is present in Choisya ternata var. Sundance. Puberulin exerts analgesic activity against chemical and heat-induced pain agents in mouse models, and this activity does not involve opioid receptors or muscarinic receptors. Puberulin can be used in the research of neuropathic pain.
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- No. CAS: 57419-60-0
- Fòrmula: C16H18O5
- Peso molecular:290.31
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Puberulin (25-300 μg/mL) exhibits good linearity in HPLC quantification, as demonstrated by a regression coefficient greater than 0.99[1].
Puberulin is successfully isolated as a colourless crystalline solid from Choisya ternata var. Sundance ethanol extract using countercurrent chromatography, with purity confirmed by HPLC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Puberulin (0.3-10 mg/kg; p.o.; single dose) exerts antinociceptive activity against Glutamate (HY-14608)-induced pain in male Swiss Webster mice at oral doses of 0.3 mg/kg and 1 mg/kg, but not at 10 mg/kg[1].
Puberulin (10 mg/kg; p.o.; single dose) does not exhibit antinociceptive activity against Capsaicin (HY-10448)-induced pain in male Swiss Webster mice at the 10 mg/kg oral dose[1].
Puberulin (0.3-10 mg/kg; p.o.; single dose) exhibits central antinociceptive activity in male Swiss Webster mice across oral doses of 0.3 mg/kg, 1 mg/kg, and 10 mg/kg, significantly increasing hot plate nociception thresholds[1].
Puberulin (1 mg/kg; p.o.; single dose) exhibits central antinociceptive activity in male Swiss Webster mice at the 1 mg/kg oral dose that is not mediated by opioid receptors, as Naloxone (HY-17417A) does not inhibit its effect[1].
Puberulin (1 mg/kg; p.o.; single dose) exhibits central antinociceptive activity in male Swiss Webster mice at the 1 mg/kg oral dose that is not mediated by muscarinic receptors, as Atropine (HY-B1205) does not inhibit its effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss Webster (male, 2 months old, 20-25 g, formalin-induced acute pain model)[1]
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Dosage:0.3 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Reduced Formalin-induced neurogenic nociception by 62% at 0.3 mg/kg, 53% at 1 mg/kg, and 68% at 10 mg/kg.
Did not affect the inflammatory pain phase (15-30 minutes post-formalin injection).
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Animal Model:Swiss Webster (male, 2 months old, 20-25 g, glutamate-induced nociception model)[1]
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Dosage:0.3 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Inhibited Glutamate-induced nociception at 0.3 mg/kg and 1 mg/kg.
Showed no effect at 10 mg/kg.
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Animal Model:Swiss Webster (male, 2 months old, 20-25 g, hot plate thermal nociception model)[1]
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Dosage:0.3 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Significantly increased the nociception threshold, as shown by elevated AUC values relative to vehicle control at 0.3 mg/kg, 1 mg/kg, and 10 mg/kg.
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Animal Model:Swiss Webster (male, 2 months old, 20-25 g, hot plate thermal nociception model, muscarinic receptor mechanism assessment)[1]
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Dosage:1 mg/kg
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Administration:p.o.; single dose
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Result:Atropine (muscarinic receptor antagonist) did not interfere with the antinociceptive effect, as shown by no significant difference in AUC between puberulin-only and puberulin+Atropine groups.
Chemical Information
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No. CAS 57419-60-0
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Peso molecular 290.31
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Fòrmula C16H18O5
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SMILES
O=C1OC2=C(C=C1)C=C(OC)C(OC/C=C(C)/C)=C2OC
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Puberulin Related Classifications
HY-N19281 Related Classifications
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