Ralfinamide
Based on 1 publication(s) in Google Scholar
Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.21%
- No. CAS: 133865-88-0
- Fòrmula: C17H19FN2O2
- Peso molecular:302.35
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Ralfinamide
More
Actividad biológica
Na+channel[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:81 adult male Sprague–Dawley male rats (260–460 g)[1]
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Dosage:80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)
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Administration:Oral gavage; twice daily; until postoperative day 42
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Result:Suppressed neuropathic pain.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 133865-88-0
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Appearance Solid
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Peso molecular 302.35
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Fòrmula C17H19FN2O2
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Color White to off-white
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SMILES
C[C@H](NCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O
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Synonyms
FCE-26742A
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain. [Abstract]2021 Aug;42(8):1235-1247. PMID: 34103689
Solvente y solubilidad
DMSO : ≥ 125 mg/mL (413.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305. [Content Brief]
[2]. Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3074 mL | 16.5372 mL | 33.0744 mL | 82.6859 mL |
| 5 mM | 0.6615 mL | 3.3074 mL | 6.6149 mL | 16.5372 mL | |
| 10 mM | 0.3307 mL | 1.6537 mL | 3.3074 mL | 8.2686 mL | |
| 15 mM | 0.2205 mL | 1.1025 mL | 2.2050 mL | 5.5124 mL | |
| 20 mM | 0.1654 mL | 0.8269 mL | 1.6537 mL | 4.1343 mL | |
| 25 mM | 0.1323 mL | 0.6615 mL | 1.3230 mL | 3.3074 mL | |
| 30 mM | 0.1102 mL | 0.5512 mL | 1.1025 mL | 2.7562 mL | |
| 40 mM | 0.0827 mL | 0.4134 mL | 0.8269 mL | 2.0671 mL | |
| 50 mM | 0.0661 mL | 0.3307 mL | 0.6615 mL | 1.6537 mL | |
| 60 mM | 0.0551 mL | 0.2756 mL | 0.5512 mL | 1.3781 mL | |
| 80 mM | 0.0413 mL | 0.2067 mL | 0.4134 mL | 1.0336 mL | |
| 100 mM | 0.0331 mL | 0.1654 mL | 0.3307 mL | 0.8269 mL |
Ralfinamide Related Classifications
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