2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Ralfinamide mesylate

Ralfinamide mesylate  (Synonyms: FCE-26742A mesylate)

Cat. No.: HY-101437A Purity: 99.41%
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Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain.

For research use only. We do not sell to patients.

Ralfinamide mesylate

Ralfinamide mesylate Chemical Structure

CAS No. : 202825-45-4

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Based on 1 publication(s) in Google Scholar

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Ralfinamide mesylate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain[1][2].

IC50 & Target

Na+channel[1]
In Vivo

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 81 adult male Sprague–Dawley male rats (260–460 g)[1]
Dosage: 80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)
Administration: Oral gavage; twice daily; until postoperative day 42
Result: Suppressed neuropathic pain.
Molecular Weight

398.45

Formula

C18H23FN2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](NCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O.CS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (125.49 mM; ultrasonic and warming and heat to 60°C)

DMSO : 8.33 mg/mL (20.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5097 mL 12.5486 mL 25.0972 mL
5 mM 0.5019 mL 2.5097 mL 5.0195 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.5097 mL 12.5486 mL 25.0973 mL 62.7431 mL
5 mM 0.5019 mL 2.5097 mL 5.0195 mL 12.5486 mL
10 mM 0.2510 mL 1.2549 mL 2.5097 mL 6.2743 mL
15 mM 0.1673 mL 0.8366 mL 1.6732 mL 4.1829 mL
20 mM 0.1255 mL 0.6274 mL 1.2549 mL 3.1372 mL
H2O 25 mM 0.1004 mL 0.5019 mL 1.0039 mL 2.5097 mL
30 mM 0.0837 mL 0.4183 mL 0.8366 mL 2.0914 mL
40 mM 0.0627 mL 0.3137 mL 0.6274 mL 1.5686 mL
50 mM 0.0502 mL 0.2510 mL 0.5019 mL 1.2549 mL
60 mM 0.0418 mL 0.2091 mL 0.4183 mL 1.0457 mL
80 mM 0.0314 mL 0.1569 mL 0.3137 mL 0.7843 mL
100 mM 0.0251 mL 0.1255 mL 0.2510 mL 0.6274 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ralfinamide mesylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ralfinamide202825-45-4FCE-26742ASodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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