2. Ralfinamide

Ralfinamide  (Synonyms: FCE-26742A)

Cat. No.: HY-101437 Purity: 99.51%
COA Handling Instructions

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Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain.

For research use only. We do not sell to patients.

Ralfinamide Chemical Structure

Ralfinamide Chemical Structure

CAS No. : 133865-88-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 58 In-stock
10 mg USD 90 In-stock
50 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ralfinamide:

Ralfinamide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ralfinamide

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  • Purity & Documentation

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Description

Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain[1][2].

IC50 & Target

Na+channel[1]
In Vivo

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 81 adult male Sprague–Dawley male rats (260–460 g)[1]
Dosage: 80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)
Administration: Oral gavage; twice daily; until postoperative day 42
Result: Suppressed neuropathic pain.
Clinical Trial
Molecular Weight

302.34

Formula

C17H19FN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](NCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (413.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3075 mL 16.5377 mL 33.0753 mL
5 mM 0.6615 mL 3.3075 mL 6.6151 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.78%

COA (244 KB) HNMR (202 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3075 mL 16.5377 mL 33.0753 mL 82.6884 mL
5 mM 0.6615 mL 3.3075 mL 6.6151 mL 16.5377 mL
10 mM 0.3308 mL 1.6538 mL 3.3075 mL 8.2688 mL
15 mM 0.2205 mL 1.1025 mL 2.2050 mL 5.5126 mL
20 mM 0.1654 mL 0.8269 mL 1.6538 mL 4.1344 mL
25 mM 0.1323 mL 0.6615 mL 1.3230 mL 3.3075 mL
30 mM 0.1103 mL 0.5513 mL 1.1025 mL 2.7563 mL
40 mM 0.0827 mL 0.4134 mL 0.8269 mL 2.0672 mL
50 mM 0.0662 mL 0.3308 mL 0.6615 mL 1.6538 mL
60 mM 0.0551 mL 0.2756 mL 0.5513 mL 1.3781 mL
80 mM 0.0413 mL 0.2067 mL 0.4134 mL 1.0336 mL
100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8269 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ralfinamide133865-88-0FCE-26742AInhibitorinhibitorinhibit

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