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Referencia número: HY-113995A

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rel-(-)-Vesamicol

(Synonyms: rel-(-)-AH5183)

rel-(-)-Vesamicol (rel-(-)-AH5183) is the racemate of (-)-Vesamicol. (-)-Vesamicol is a vesicular acetylcholine transporter inhibitor. (-)-Vesamicol reversibly and non-competitively inhibits the transport of acetylcholine into circulating synaptic vesicles and blocks the activity of vesicular acetylcholine transporters in medial amygdala neurons. (-)-Vesamicol is applicable to research related to central precocious puberty.

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No. CAS: 115362-28-2
Fòrmula: C₁₇H₂₅NO
Peso molecular:259.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

rel-(-)-Vesamicol Chemical Structure

No. CAS: 115362-28-2

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Descripciòn

Ver todos los productos específicos de isoformas mAChR :

In Vivo

rel-(-)-Vesamicol (20 mmol; stereotactic injection) significantly delays precocious puberty onset induced by sexual content stimuli, reduces the serum LH/FSH ratio, and decreases kisspeptin expression in the ARC of female Sprague-Dawley rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 115362-28-2
Peso molecular 259.39
Fòrmula C₁₇H₂₅NO
SMILES

O[C@H]1[C@H](N2CCC(C3=CC=CC=C3)CC2)CCCC1
Synonyms

rel-(-)-AH5183
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Searl T, et al. Acetylcholine recycling and release at rat motor nerve terminals studied using (-)-vesamicol and troxpyrrolium. The Journal of physiology. 1991 Dec;444:99-116. [Content Brief]

[2]. Shen Y, et al. Early Exposure of an Infantile Rat to Sex-Related Content Induces Precocious Puberty by Activation of Cholinergic Neurons in the Amygdala and KNDy Neurons in the Arcuate Nucleus. ACS omega. 2025 Jul 22;10(28):30327-30334. [Content Brief]

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rel-(-)-Vesamicol

Ver todos los productos específicos de isoformas mAChR

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rel-(-)-Vesamicol Related Classifications

HY-113995A Related Classifications