PROTAC RIPK2 Degrader-1
RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor. RIPK2-IN-2 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases.
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- No. CAS: 2143956-20-9
- Fòrmula: C53H65FN14O7S2
- Peso molecular:1093.30
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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RIPK2 |
RIPK2-IN-2 (example 25) can simultaneously bind RIP2 kinase and an E3 ubiquitin ligase (VHL), which promotes ubiquitination of RIP2 Kinase and leads to RIP2 kinase degradation by the proteasome. through proteolysis targeting chimeric molecules PROTACs technology, RIPK2-IN-2 (example 25) can promotes ubiquitination of RIP2 Kinaseand degrade RIP2 kinase with the concentrations of RIPK2-IN-2﹤1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP1 cells
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Concentration:﹤1 μM
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Incubation Time:12 h
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Result:Displayed > 80% degradation of RIP2 at concentrations ﹤1 μM.
Chemical Information
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No. CAS 2143956-20-9
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Peso molecular 1093.30
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Fòrmula C53H65FN14O7S2
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SMILES
O=C(N1CCC(CC1)[C@H](NC([C@H](C)NC)=O)C(N2[C@@](C3=NC(C(C4=CC=C(C=C4)F)=O)=CS3)([H])CCC2)=O)C5=CN=C(N=C5)N(CC6)CCN6CCOC(C(S(C(C)(C)C)(=O)=O)=C7)=CC8=C7C(NC9=NNC(C)=C9C)=NC=N8
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC RIPK2 Degrader-1 Related Classifications
HY-147235 Related Classifications
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