RX-RA-69
RX-RA-69 is an orally active platelet phosphodiesterase (PDE) inhibitor with a IC50 of 1 nM. RX-RA-69 elevates cAMP levels in platelets, exerts anti-aggregatory effects, and inhibits the formation of coronary platelet thrombi. RX-RA-69 exhibits anti-metastatic activity in a mouse Lewis lung cancer model. RX-RA-69 can be used in research related to coronary platelet thrombi and Lewis lung cancer.
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- No. CAS: 77749-49-6
- Fòrmula: C21H25N7OS
- Peso molecular:423.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
RX-RA 69 inhibits tumor cell-induced platelet aggregation in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
RX-RA 69 (1 mg/kg; p.o.) exhibits anti-metastatic activity in a mouse Lewis lung cancer model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mongrel dogs (either sex, weight 19.5-29.0 kg, modified Folts model)[1]
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Dosage:60 μg/kg (i.v. bolus); 120 μg/kg (i.v. bolus); 1.0 ng/kg/min (i.c. infusion); 3.0 ng/kg/min (i.c. infusion); 10.0 ng/kg/min (i.c. infusion)
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Administration:i.v. (single bolus); i.c. (infusion, 30 min)
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Result:Reduced the resistance of blood vessels throughout the body, resulting in a systemic decrease in blood pressure.
Increased myocardial contractility (increase the maximum ascending rate of left ventricular pressure).
Chemical Information
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No. CAS 77749-49-6
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Peso molecular 423.53
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Fòrmula C21H25N7OS
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SMILES
C1(N=CN=C2SCC3=CC=CC=C3)=C2N=C(N4CCNCC4)N=C1N5CCOCC5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Machleidt C, et al. Prevention of coronary platelet aggregation with a phosphodiesterase inhibitor RX-RA 69. Thromb Res. 1985;37(5):595-604. [Content Brief]
[2]. Lichtner R, et al. Antimetastatic action of RX-RA 69, a new potent PDE-inhibitor in the Lewis lung carcinoma of the mouse. Prog Clin Biol Res. 1982;89:131-141. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RX-RA-69 Related Classifications
HY-182415 Related Classifications
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