SB-258585
Based on 1 Customer Validation
SB-258585 is a selective ligand with high affinity for the 5-HT6 receptor, with a pKi value of 8.53.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.77%
- No. CAS: 209480-63-7
- Fòrmula: C18H22IN3O3S
- Peso molecular:487.36
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Ver todos los productos específicos de isoformas 5-HT Receptor
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Actividad biológica
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5-HT6 Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Astrocyte | CC50 |
>1 μM
Compound: SB258585
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Toxicity in mouse C8-D1A astrocytes assessed as reduction in cell viability by MTT assay
Toxicity in mouse C8-D1A astrocytes assessed as reduction in cell viability by MTT assay
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[PMID: 33439019] |
| HeLa | IC50 |
0.019 μM
Compound: SB-258585
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Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation pretreated for 10 mins before 5-HT addition measured after 30 mins
Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation pretreated for 10 mins before 5-HT addition measured after 30 mins
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[PMID: 23820387] |
Chemical Information
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No. CAS 209480-63-7
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Appearance Solid
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Peso molecular 487.36
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Fòrmula C18H22IN3O3S
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Color Light yellow to yellow
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SMILES
O=S(C1=CC=C(I)C=C1)(NC2=CC=C(OC)C(N3CCN(C)CC3)=C2)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (102.59 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0519 mL | 10.2594 mL | 20.5187 mL | 51.2968 mL |
| 5 mM | 0.4104 mL | 2.0519 mL | 4.1037 mL | 10.2594 mL | |
| 10 mM | 0.2052 mL | 1.0259 mL | 2.0519 mL | 5.1297 mL | |
| 15 mM | 0.1368 mL | 0.6840 mL | 1.3679 mL | 3.4198 mL | |
| 20 mM | 0.1026 mL | 0.5130 mL | 1.0259 mL | 2.5648 mL | |
| 25 mM | 0.0821 mL | 0.4104 mL | 0.8207 mL | 2.0519 mL | |
| 30 mM | 0.0684 mL | 0.3420 mL | 0.6840 mL | 1.7099 mL | |
| 40 mM | 0.0513 mL | 0.2565 mL | 0.5130 mL | 1.2824 mL | |
| 50 mM | 0.0410 mL | 0.2052 mL | 0.4104 mL | 1.0259 mL | |
| 60 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8549 mL | |
| 80 mM | 0.0256 mL | 0.1282 mL | 0.2565 mL | 0.6412 mL | |
| 100 mM | 0.0205 mL | 0.1026 mL | 0.2052 mL | 0.5130 mL |
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