SCR007
SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics.
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- No. CAS: 2409183-72-6
- Fòrmula: C36H30N4S4
- Peso molecular:646.91
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
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| Vero | IC50 |
>100 μM
Compound: SCR-9
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Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs
Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs
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[PMID: 30925051] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 103 PFU of SARS-CoV-1/2[1]
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Dosage:3 mg/kg
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Administration:i.n., single dose
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Result:Achieved 90% survival rate.
Reduced lung viral RNA copies by multiple orders of magnitude and brain viral RNA copies significantly.
Decreased perivascular infiltrates and necrotic neurons in lung and brain tissues.
Reduced lung live virus titer.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with TNFα, IL-18 and IFN-γ reduced.
Chemical Information
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No. CAS 2409183-72-6
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Peso molecular 646.91
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Fòrmula C36H30N4S4
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SMILES
C1(C/N=C/C2=CC=CS2)=CC(C3=CC(C/N=C/C4=CC=CS4)=CC(C/N=C/C5=CC=CS5)=C3)=CC(C/N=C/C6=CC=CS6)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SCR007 Related Classifications
HY-178137 Related Classifications
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