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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Target:
Áreas de investigación:
Poloxamer L62 is a nonionic polyoxyethylene-polyoxypropylene block copolymer triblock surfactant. Poloxamer L62 interacts with the surfactant-liposome bilayer, causing minimal membrane disruption. Poloxamer L62 exhibits a decrease in critical micelle temperature, critical micelle concentration, and cloud point in ionic liquids, with minimal effect on micelle morphology. Within the tested surfactant concentration range, Poloxamer L62 has minimal effect on the release of encapsulated ciprofloxacin (Ciprofloxacin) (HY-B0356). Poloxamer L62 does not significantly alter the vesicle size of liposomal ciprofloxacin formulations .
Referencia número: HY-D3160
Target:
Áreas de investigación:
Golgi-hNR is a cell membrane-permeable Golgi-targeted fluorescent probe containing a sulfonamide group. Golgi-hNR selectively accumulates in the Golgi apparatus of living cells, enabling real-time tracking and homeostasis assessment of reversible pH changes in the Golgi apparatus. Golgi-hNR exhibits a pH-dependent "off-on" fluorescence response mechanism within the pH 7.4-3.0 range, and its red fluorescence intensity decreases with increasing pH. The Ex/Em of Golgi-hNR is 560/664 nm and 580/664 nm, with the maximum emission peak located at 615 nm .
Referencia número: HY-D3163
Target:
Áreas de investigación:
Endo-pH is a cell-permeable, pH-responsive fluorescent probe based on BODIPY, with a pKa of 5.08. When pH decreases from 7.32 to 4.97, Endo-pH undergoes protonation under acidic conditions, resulting in a 79-fold increase in fluorescence intensity at 786 nm. The detection wavelengths of its protonated form are Ex/Em=688/786 nm, while the absorption wavelength of its non-protonated form is 745 nm. Endo-pH can be used for staining late endosomes in live cells and determining the fusion time of late endosomes and lysosomes .
Referencia número: HY-E71278
Target:
Áreas de investigación:
β-Carotene 15,15'-dioxygenase (EC 1.13.11.63) requires Fe2+. The enzyme cleaves β-Carotene symmetrically, producing two molecules of all-trans-retinal. Both atoms of the oxygen molecule are incorporated into the products. The enzyme can also process β-cryptoxanthin, 8'-apo-β-carotenal, 4'-apo-β-carotenal, α-carotene and γ-carotene in decreasing order. The presence of at least one unsubstituted β-ionone ring in a substrate greater than C30 is mandatory.
Referencia número: HY-N0136B
No. CAS: 111003-33-9
Synonyms: (-)-Dihydroquercetin
Referencia número: HY-N12267
No. CAS: 42369-86-8
Synonyms: (E/Z)-Terrestribisamide
Synonyms: NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether
Target:
Referencia número: HY-P0165B
No. CAS: 1022150-16-8
Synonyms: ITM077 acetate; R1583 acetate; BIM51077 acetate
Target:
Áreas de investigación:
Referencia número: HY-P2483A
Target:
Áreas de investigación:
Referencia número: HY-P992552
Synonyms: F8-IL10、PF-06687234
Target:
Áreas de investigación:
Dekavil (F8-IL10, PF-06687234) is an agent targeting the IL10 receptor (IL10 receptor) that mediates anti-inflammatory cytokine signaling. Dekavil can induce cytokine-dependent mast cell proliferation. Dekavil can inhibit the progression of established collagen-induced arthritis, reduce plasma levels of pro-inflammatory IL-6 and IL-1 beta, and decrease the infiltration of leukocytes, natural killer cells, macrophages, and T cells into the arthritic paws. Dekavil can be used in research on rheumatoid arthritis .
Referencia número: HY-W009156R
No. CAS: 6100-05-6
Synonyms: Potassium citrate monohydrate (Standard)
Referencia número: HY-W014223R
No. CAS: 131-56-6
Synonyms: Ultraviolet absorber UV-0 (Standard)
Áreas de investigación:
2,4′-Dihydroxybenzophenone (Standard) is the analytical standard of 2,4′-Dihydroxybenzophenone. This product is intended for research and analytical applications. 2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber .
Referencia número: HY-W099504
No. CAS: 111-70-6
Synonyms: n-Heptyl alcohol
Referencia número: HY-W724319
No. CAS: 2704-20-3
Synonyms: Sodium citrate-d4; Trisodium citrate anhydrous-d4
Áreas de investigación:
Ethylenediaminetetraacetic acid (Standard) is the analytical standard of Ethylenediaminetetraacetic acid. This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research [4] .
Referencia número: HY-P5522AS
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid-13C3,15N dihydrochloride
Target:
Isotope-Labeled Compounds NOD-like Receptor (NLR) NF-κB MAP3K MEK ERK p38 MAPK Interleukin Related SARS-CoV
Áreas de investigación:
TriDAP- 13C3, 15N (L-Ala-γ-D-Glu-meso-diaminopimelic acid- 13C3, 15N) dihydrochloride is the 13C, 15N-labeled TriDAP dihydrochloride (HY-P5522A). TriDAP dihydrochloride (L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride) is a NOD1 agonist with a Kd value of 34.5 μM. TriDAP dihydrochloride enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, MEK/ERK, p38 and interferon response pathways. TriDAP dihydrochloride downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP dihydrochloride decreases IκBα levels and increases p65 levels. TriDAP dihydrochloride induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP dihydrochloride increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP dihydrochloride can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection .
Referencia número: HY-101986R
No. CAS: 246146-55-4
Synonyms: AR-H 053591 (Standard)
Áreas de investigación:
BIIE-0246 (Standard) is the analytical standard of BIIE-0246 (HY-101986). This product is intended for research and analytical applications. BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy .
Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent Gli antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC50 value of 1.1 µM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner .
Referencia número: HY-110107A
No. CAS: 469861-48-1
Target:
Áreas de investigación:
GW438014A free base is a selective NPY-Y5 receptor competitive antagonist capable of crossing the blood-brain barrier, with IC50 values of 197 nM and 211 nM against human receptors. GW438014A free base reverses PYY-mediated inhibition of Forskolin (HY-15371)-induced cAMP production, reduces NPY-induced food intake and nocturnal food intake in rodents, decreases body weight gain and fat mass in Zucker rats, and inhibits centrally mediated feeding behavior. GW438014A free base can be used in research related to obesity and epilepsy .
Referencia número: HY-111431AR
No. CAS: 91978-69-7
Synonyms: p-Tolyl sulfate potassium (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
