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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Referencia número: HY-188400
No. CAS: 3138013-03-0
Áreas de investigación:
P-SiaFNEtoc is a Sialyltransferase inhibitor that blocks sialic acid capping of glycans. P-SiaFNEtoc forms CMP-SiaFNEtoc, reduces endogenous CMP-Neu5Ac, feedback-inhibits GNE, and depletes sialylation on N-glycans and O-GalNAc glycans. P-SiaFNEtoc decreases cell surface sialoglycan levels, VEGF and DKK-1 secretion, Tn antigen levels, and cell cycle checkpoint/E2F target gene expression, while inducing p27/Kip1 and fucosylation. P-SiaFNEtoc can be used in research on prostate cancer, and melanoma .
Referencia número: HY-189128
No. CAS: 774546-16-6
AN-465 is a METTL3 inhibitor with an IC50 of 1.782 μM and a Kd of 8.75 μM against human METTL3. AN-465 reduces m6A modification of RNA, including EV71 2C region RNA, and disrupts the interaction between METTL3 and EV71 2C RNA. AN-465 decreases EV71-induced proinflammatory cytokine production, modulates immune cell phenotypes, alleviates EV71-induced apoptosis, restores autophagic flux, and reduces viral particle formation. AN-465 is used in the study of hand, foot and mouth disease .
Referencia número: HY-189933
No. CAS: 920836-30-2
Target:
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) SHP1 SHP2 STAT IFNAR Interleukin Related
Áreas de investigación:
ICB-7 is an orally active ILT3/LILRB4 inhibitor with a Kd of 156 nM for hILT3 and a Kd of 262 nM for mouse ILT3. ICB-7 reduces SCG2-induced phosphorylation of SHP1, SHP2, and STAT3. In a co-culture model, ICB-7 restores IFN-γ and IL-2 secretion and decreases cell viability under SCG2 stimulation. In a syngeneic cancer model, ICB-7 inhibits tumor progression and reduces final tumor weight. ICB-7 can be used for research on colorectal cancer and acute myeloid leukemia .
Referencia número: HY-208723
No. CAS: 2345648-39-5
MAP3K1-IN-1 is an orally active and selective MAP3K1 kinase inhibitor. MAP3K1-IN-1 blocks TNFα-induced phosphorylation of IKKβ and activation of NF-κB. MAP3K1-IN-1 inhibits the growth of cancer cells. MAP3K1-IN-1 induces a decrease in phosphorylation sites of NPM1. MAP3K1-IN-1 can be used in pancreatic cancer-related research .
Target:
Áreas de investigación:
Doxylamine succinate is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine succinate is orally active, possessing analgesic and hypnotic activities. Doxylamine succinate enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine succinate decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine succinate induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine succinate can be used for the research of nausea, allergy, insomnia .
Referencia número: HY-B0011B
No. CAS: 700367-34-6
Synonyms: RP-56976 hydrate
Áreas de investigación:
Docetaxel hydrate (RP-56976 hydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel hydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel hydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel hydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel hydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel hydrate can be used in cancer-related research .
Referencia número: HY-B0579S3
Synonyms: Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4; CsA-13C2,d4
Referencia número: HY-B0852R
No. CAS: 107534-96-3
Áreas de investigación:
Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
Referencia número: HY-B0852S2
Referencia número: HY-B1455S1
No. CAS: 2140264-63-5
Synonyms: 4,4'-DDD (Standard); p,p'-Dichlorodiphenyl dichloroethane (Standard)
Áreas de investigación:
p,p'-DDD (Standard) is the analytical standard of p,p'-DDD (HY-B1984) . This product is intended for research and analytical applications. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats.
Referencia número: HY-B1984S
No. CAS: 93952-20-6
Synonyms: 4,4'-DDD-d8; p,p'-Dichlorodiphenyl dichloroethane-d8
Referencia número: HY-D0877
No. CAS: 29915-38-6
Referencia número: HY-N0046
No. CAS: 88105-29-7
Synonyms: Notoginseng triterpenes; Ginsenoside Mb
Referencia número: HY-N0433R
No. CAS: 84676-89-1
Synonyms: Astrasieversianin VIII (Standard)
Synonyms: NSC 3778 (Standard); O-Methylsalicylic acid (Standard); Salicylic acid methyl ether (Standard)
Referencia número: HY-N14780
No. CAS: 544712-82-5
Synonyms: (+)-Pochonin D
Category:
Referencia número: HY-N17963
No. CAS: 229483-41-4
Referencia número: HY-N6682R
No. CAS: 22144-77-0
Synonyms: Zygosporin A (Standard); NSC 209835 (Standard)
Category:
Referencia número: HY-N6801S
No. CAS: 911392-40-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
