country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-149846

Copy Link Print Information

SIQ17

SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC₅₀ of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC₅₀ of ∼20 nM). SIQ17 can be used for cancer research

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2151881-74-0
Fòrmula: C₃₂H₂₇NO₂S
Peso molecular:489.63

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SIQ17 Chemical Structure

No. CAS: 2151881-74-0

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas EGFR :

In Vitro

SIQ17 (10 μM, 72 hours) has a stronger inhibits on cell viability of A431 cells compare to A549 cells^[1].
SIQ17 (0-100 μM, 24 hours) has thecytotoxic effects, with IC₅₀s of 32.98 μM and 19.17μM for A549 cells and A431 cells respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

A549, A431
Concentration:

10 μM
Incubation Time:

72 hours
Result:

Had a stronger inhibits on cell viability of A431 cells compare to A549 cells

Cell Cytotoxicity Assay^[1]

Cell Line:

A549, A431, Vero cell lines
Concentration:

0-100 μM
Incubation Time:

24 hours
Result:

Had thecytotoxic effects, with IC₅₀s of 32.98μM and 19.17μM for A549 cells and A431 cells respectively.

Chemical Information

No. CAS 2151881-74-0
Peso molecular 489.63
Fòrmula C₃₂H₂₇NO₂S
SMILES

O=S(C(C1=C2C=CC=C1)=C3C2=C(C4=CC=C(C)C=C4C)N(C)C5=C3C=CC=C5)(C6=CC=C(C)C=C6)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Hengphasatporn K,et.al. Sulfonylated Indeno[1,2-c]quinoline Derivatives as Potent EGFR Tyrosine Kinase Inhibitors. ACS Omega. 2023 May 23;8(22):19645-19655. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto