Spectramide
Spectramide is a blood-brain barrier-permeable, reversible, and selective dopamine D2 receptor ligand. Spectramide shows no strong interactions with dopamine D1 receptors, dopamine uptake sites, adrenergic receptor systems, cholinergic receptor systems, or 5-HTR systems. Spectramide can be labeled with 11C or 123I isotopes for use in PET or SPECT. Spectramide preferentially accumulates in the striatum with low uptake in other brain regions, and its accumulation can be blocked by pre-administration of Haloperidol (HY-14538).
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- No. CAS: 125141-02-8
- Fòrmula: C19H23ClIN3O2
- Peso molecular:487.76
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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D2 Receptor |
125I-Spectramide (increasing concentrations; 30 minutes) binds to a single population of high-affinity dopamine D2 receptors in rat striatal homogenates with a Kd of 25 pM and a Bmax of 20 pmol/g tissue[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 125141-02-8
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Peso molecular 487.76
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Fòrmula C19H23ClIN3O2
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SMILES
O=C(C1=CC(Cl)=C(NC)C=C1OC)NCCN(CC2=CC=C(C=C2)I)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Spectramide Related Classifications
HY-183927 Related Classifications
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