SR-THAP
SR-THAP is a γ-aminobutyric acid transporter 3 (GAT3) inhibitor with an IC50 of 4.9 μM, and exhibits 42-fold and 23-fold selectivity over GAT1 and GlyT1, respectively. SR-THAP inhibits GABA uptake in mammalian cells. SR-THAP is applicable to the research of epilepsy, Alzheimer's disease and ischemic stroke.
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- No. CAS: 3098361-74-8
- Fòrmula: C31H35NO6
- Peso molecular:517.61
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
SR-THAP (0-1000 μM; 120 min preincubation + 3 min uptake) inhibits hGAT3C316S mutant-mediated [3H]GABA uptake in HEK293T cells with reduced potency (IC50 = 10.6 μM) compared to wild-type hGAT3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3098361-74-8
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Peso molecular 517.61
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Fòrmula C31H35NO6
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SMILES
COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)/C=C/CN4CCC[C@]4([H])[C@@H](C(O)=O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SR-THAP Related Classifications
HY-181961 Related Classifications
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