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Referencia número: HY-106412

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Stacofylline

(Synonyms: S 9977 free base; S 9977-2 free base)

Stacofylline (S 9977 free base; S 9977-2 free base), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC₅₀ of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities.

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No. CAS: 98833-92-2
Fòrmula: C₂₀H₃₃N₇O₃
Peso molecular:419.52

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Stacofylline Chemical Structure

No. CAS: 98833-92-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

AChE

5-50 nM (IC₅₀)

Ver todos los productos específicos de isoformas Cholinesterase (ChE) :

AChE
BChE

In Vitro

Stacofylline potentiates cholinergic transmission by significantly increasing the time constant of decay (Tc) of inhibitory postsynaptic currents (IPSCs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Stacofylline (0.0312-0.5 mg/kg; p.o.) clearly attenuates the memory deficits induced by the three amnesic treatments after acute treatment in Scopolamine, Diazepam, and electroconvulsive shock (ECS) mouse models,^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 98833-92-2
Peso molecular 419.52
Fòrmula C₂₀H₃₃N₇O₃
SMILES

CN1C2=C(N(C(N(C)C2=O)=O)C)N=C1CCCN3CCN(C(N(CC)CC)=O)CC3
Synonyms

S 9977 free base; S 9977-2 free base
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. L E Trudeau, et al. Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85. [Content Brief]

[2]. Roger D. Porsolt, et al. Potential cognition-enhancing properties of S 9977 in three moenls of amnesia in the mouse. Drug Development Research. 1992.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
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Stacofylline

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas Cholinesterase (ChE)

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Help & FAQs

Stacofylline Related Classifications

HY-106412 Related Classifications