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Referencia número: HY-168043

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STAT3-IN-35

STAT3-IN-35 is a STAT3 inhibitor that binds to SH2 domain. STAT3-IN-35 inhibits the phosphorylation of STAT3 and possesses antiproliferative activities against triple-negative breast cancer (TNBC) cell lines. STAT3-IN-35 also has a toxicity and potent antitumor activity in a TNBC xenograft model.

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No. CAS: 2849535-96-0
Fòrmula: C₂₁H₂₃NO₄
Peso molecular:353.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

STAT3-IN-35 Chemical Structure

No. CAS: 2849535-96-0

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas STAT :

Cellular Effect

Cell Line	Type	Value	Description	References
L02	IC₅₀	>20 μM Compound: 10g	Antiproliferative activity against human L02 cells assessed as cell viability incubated for 48 hrs measured after additional incubation with MTT Antiproliferative activity against human L02 cells assessed as cell viability incubated for 48 hrs measured after additional incubation with MTT	[PMID: 39226127]
MCF-10A	IC₅₀	>20 μM Compound: 10g	Antiproliferative activity against human MCF-10A cells assessed as cell viability incubated for 48 hrs measured after additional incubation with MTT Antiproliferative activity against human MCF-10A cells assessed as cell viability incubated for 48 hrs measured after additional incubation with MTT	[PMID: 39226127]
MDA-MB-231	IC₅₀	2.05 μM Compound: 10g	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs measured after additional incubation with MTT Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs measured after additional incubation with MTT	[PMID: 39226127]
MDA-MB-468	IC₅₀	7.54 μM Compound: 10g	Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability incubated for 48 hrs measured after additional incubation with MTT Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability incubated for 48 hrs measured after additional incubation with MTT	[PMID: 39226127]

Chemical Information

No. CAS 2849535-96-0
Peso molecular 353.41
Fòrmula C₂₁H₂₃NO₄
SMILES

O=C(C1=O)C2=CC=CC=C2C3=C1C4=C(O3)CN(CC4)[C@H](CO)CC(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Fan C, et al. Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15291-15310. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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STAT3-IN-35

Ver todos los productos específicos de isoformas STAT

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

STAT3-IN-35 Related Classifications

HY-168043 Related Classifications