TC2
TC2 is an efficient GIPR-preferring monomeric quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.47, 2.1, 30, and 55 nM respectively. TC2 exhibits a significant GLP-1R preference, with a significant reduction in β-inhibitory protein 2 (βArr2) recruitment, while maintaining a strong cAMP signal. TC2 can be used for research on obesity and diabetes.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C263H407N67O72
- Peso molecular:5659.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Neuropeptide Y Receptor
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Actividad biológica
Chemical Information
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Peso molecular 5659.45
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Fòrmula C263H407N67O72
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Sequence
Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(γGlu-C16 acid)-Ser-Ile-Leu-Leu-Asp-Arg-Lys-Ala-Gln-Ala-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Leu-Arg-His-Tyr-Val-Asn-Trp-Leu-Thr-Arg-Gln-Arg-Tyr-NH2
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Sequence Shortening
Y-{Aib}-QGTFTSD-Lys(γGlu-C16 acid)-SILLDRKAQAAFIEYLLEGGPSLRHYVNWLTRQRY-NH2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TC2 Related Classifications
HY-P11279 Related Classifications
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