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Referencia número: HY-126489

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Tetromycin B

Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC₅₀=30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC₅₀s=71.77 and 20.2 μM, respectively).

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No. CAS: 180027-84-3
Fòrmula: C₃₄H₄₆O₅
Peso molecular:534.73

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tetromycin B Chemical Structure

No. CAS: 180027-84-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

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Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H460	IC₅₀	>30 μM Compound: 11	Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]
SW-620	IC₅₀	>30 μM Compound: 11	Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]

Chemical Information

No. CAS 180027-84-3
Peso molecular 534.73
Fòrmula C₃₄H₄₆O₅
SMILES

CC1=C[C@]2([C@@]([H])([C@H](CC[C@@H]2O)C)[C@@](C)([C@@]1(/C(C)=C/CC/C(C)=C/[C@]3([C@]4(C[C@H](C(C)=C3)C)OC5=O)C)[H])C(C5=C4O)=O)[H]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Pimentel-Elardo, et al. New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities. Mar. Drugs 9(10), 1682-1697 (2011).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Tetromycin B

Ver todos los productos específicos de isoformas Parasite

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Tetromycin B Related Classifications

HY-126489 Related Classifications