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Tidutamab

(Synonyms: XmAb-18087)
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Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC).

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 96.71%
  • No. CAS: 2148354-90-7
  • Peso molecular:150.74 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tidutamab
  • Experimental Validation Results for Tidutamab
  • Experimental Validation Results for Tidutamab
  • Experimental Validation Results for Tidutamab
  • Tidutamab Chemical Structure
    Tidutamab Chemical Structure
No. CAS: 2148354-90-7
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Tidutamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    half-IGG1-kappa/(scFv-heavy-lambda)-h-CH2-CH3

  • 1/16

    Immobilized SSTR2 Protein-VLP, Human (HEK293, His, HY-P700430) can bind Tidutamab. The EC50 for this effect is 61.59 ng/mL.

  • 1/16

    Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Tidutamab. The EC50 for this effect is 443.3 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tidutamab (HY-P99562). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Tidutamab Chemical Structure
    1/16
  • Tidutamab
  • Immobilized SSTR2 Protein-VLP, Human (HEK293, His, HY-P700430) can bind Tidutamab. The EC50 for this effect is 61.59 ng/mL.
  • Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Tidutamab. The EC50 for this effect is 443.3 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tidutamab (HY-P99562). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • half-IGG1-kappa/(scFv-heavy-lambda)-h-CH2-CH3