2. Immunology/Inflammation
  3. CD3
  4. Tidutamab

Tidutamab  (Synonyms: XmAb-18087)

Cat. No.: HY-P99562

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Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC).

For research use only. We do not sell to patients.

Tidutamab Chemical Structure

Tidutamab Chemical Structure

CAS No. : 2148354-90-7

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Tidutamab Related Antibodies

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Description

Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC)[1].

In Vitro

Tidutamab (XmAb-18087; 0-100.000 ng/mL) binds to human SSTR2+ CHO cells with an ED50 value of 2.2 μg/mL and mediates T cell killing of SSTR2+ target cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tidutamab Related Antibodies
In Vivo

Tidutamab (XmAb-18087; 3 mg/kg; i.p.; single dose) stimulates human T cell killing of SSTR2+ A549 lung carcinoma tumors in NSG mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice[1]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; single dose
Result: lnduced anti-tumor activity in human PBMC-engrafted NSG mice.
Clinical Trial
CAS No.
SMILES

[Tidutamab]
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Tidutamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tidutamab2148354-90-7XmAb-18087XmAb18087XmAb 18087CD3Cluster of differentiation 3T-cellFc domainhalf-lifeserumSSTR+ tumorRTcCInhibitorinhibitorinhibit

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