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Referencia número: HY-118528

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TP0427736

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

TP0427736 is a selective inhibitor of ALK5 with an IC₅₀ of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells.

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No. CAS: 864374-00-5
Fòrmula: C₁₄H₁₀N₄S₂
Peso molecular:298.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

TP0427736 Chemical Structure

No. CAS: 864374-00-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

Ver todos los productos específicos de isoformas TGF-β Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8.7 nM Compound: 3a	Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 hr by fluorescence analysis Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 hr by fluorescence analysis	[PMID: 23117174]

Chemical Information

No. CAS 864374-00-5
Peso molecular 298.39
Fòrmula C₁₄H₁₀N₄S₂
SMILES

CC1=CSC(C2=C(NC=N2)C3=CC=C4N=CSC4=C3)=N1
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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J Clin Invest

Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communications. [Abstract]

2024 Jun 18;134(16):e178303. PMID: 38889010
Commun Biol

Wnt11 mediates fibroblast-smooth muscle cell interaction to promote neurogenic bladder fibrosis in rats. [Abstract]

2026 Feb 9;9(1):194. PMID: 41663583

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491. [Content Brief]

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TP0427736

2 Cited Publications

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TP0427736

Publications Citing Use of MedChemExpress (MCE) TP0427736

Ver todos los productos específicos de isoformas TGF-β Receptor

Actividad biológica

Chemical Information

Publications (2)

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Referencias

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TP0427736 Related Classifications

HY-118528 Related Classifications