WRR139
Based on 3 publication(s) in Google Scholar
WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells.
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- Pureza: 99.71%
- No. CAS: 2138924-36-2
- Fòrmula: C25H32N2O4S
- Peso molecular:456.60
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) WRR139
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Actividad biológica
WRR139 (0.01-100 μM; 1 h) inhibits NGLY1 in vitro and impairs processing of Nrf1 in HEK293 cells[1].
WRR139 (5 μM; 18 h) disrupts Nrf1 processing, location, and activation in HEK293 cells[1].
WRR139 (1 μM; 24 h) enhances the cytotoxicity of Carfilzomib in an NGLY1-dependent manner in U266, H929, and Jurkat cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2138924-36-2
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Appearance Solid
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Peso molecular 456.60
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Fòrmula C25H32N2O4S
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Color White to off-white
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SMILES
O=C(NCCC(C)C)[C@@H](NC(/C=C/S(C1=CC=C(C)C=C1)(=O)=O)=O)CCC2=CC=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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J Anim Sci Biotechnol
The ameliorative role of phlorotannin on aflatoxin B1-induced liver oxidative stress and mitochondrial injury is related to the activation of Nrf2 and Nrf1 signaling pathways in broilers. [Abstract]2025 May 22;16(1):75. PMID: 40405298
WRR139 purchased from MedChemExpress. Usage Cited in: J Anim Sci Biotechnol. 2025 May 22;16(1):75. [Abstract]
Relative mRNA levels of Nrf1 pathway-related gene in AFB1-induced LMH cells treated with WRR139 (10 μM).
WRR139 purchased from MedChemExpress. Usage Cited in: J Anim Sci Biotechnol. 2025 May 22;16(1):75. [Abstract]
Western blot analysis of total and nuclear Nrf1 in AFB1-induced LMH cells treated with WRR139 (10 μM).
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bioRxiv
2026 Mar 28:2026.03.27.711928. PMID: 41929138 -
Solvente y solubilidad
DMSO : 100 mg/mL (219.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1901 mL | 10.9505 mL | 21.9010 mL | 54.7525 mL |
| 5 mM | 0.4380 mL | 2.1901 mL | 4.3802 mL | 10.9505 mL | |
| 10 mM | 0.2190 mL | 1.0951 mL | 2.1901 mL | 5.4753 mL | |
| 15 mM | 0.1460 mL | 0.7300 mL | 1.4601 mL | 3.6502 mL | |
| 20 mM | 0.1095 mL | 0.5475 mL | 1.0951 mL | 2.7376 mL | |
| 25 mM | 0.0876 mL | 0.4380 mL | 0.8760 mL | 2.1901 mL | |
| 30 mM | 0.0730 mL | 0.3650 mL | 0.7300 mL | 1.8251 mL | |
| 40 mM | 0.0548 mL | 0.2738 mL | 0.5475 mL | 1.3688 mL | |
| 50 mM | 0.0438 mL | 0.2190 mL | 0.4380 mL | 1.0951 mL | |
| 60 mM | 0.0365 mL | 0.1825 mL | 0.3650 mL | 0.9125 mL | |
| 80 mM | 0.0274 mL | 0.1369 mL | 0.2738 mL | 0.6844 mL | |
| 100 mM | 0.0219 mL | 0.1095 mL | 0.2190 mL | 0.5475 mL |
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