YLT-11
YLT-11 is a potent, selective and orally active PLK4 inhibitor with Kd values of >10000, 653, >10000, 5.2 nM for PLK1, PLK2, PLK3, PLK4, respectively. YLT-11 shows antiproliferative activity. YLT-11 induces Apoptosis and cell cycle arrest at G2/M phase. YLT-11 show anticancer activity.
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- No. CAS: 3040940-49-3
- Fòrmula: C24H24N6O
- Peso molecular:412.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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PLK4 5.2 nM (Kd) |
PLK2 653 nM (Kd) |
PLK1 >10000 nM (Kd) |
PLK3 >10000 nM (Kd) |
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Cell Line
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Type | Value | Description | References |
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| Breast carcinoma cell | IC50 |
60 nM
Compound: 12; YLT-11
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Antiproliferative activity against human TNBC cells assessed as reduction in cell viability
Antiproliferative activity against human TNBC cells assessed as reduction in cell viability
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[PMID: 38199166] |
YLT-11 (0-1 µM; 48 h) decreases the expression of p-PLK4 in a dose-dependent manner[1].
YLT-11 (0-0.5 µM; 0-48 h) induces apoptosis and cell cycle arrest at G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, MDA-MB-468, BT549, MCF-7 cells
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Concentration:0-10 µM
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Incubation Time:24-96 h
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Result:Showed antiproliferative activity in a time-dependent and concentration-dependent manner with IC50s of 120, 68, 73, 74 nM for MDA-MB-231, MDA-MB-468, BT549, MCF-7 cells, respectively.
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Cell Line:MDA-MB-468, MDA-MB-231 cells
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Concentration:0, 0.25, 0.5, 1 µM
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Incubation Time:48 h
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Result:Decreased the expression of p-PLK4 in a dose-dependent manner.
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Cell Line:MDA-MB-468, MDA-MB-231 cells
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Concentration:0.25 µM
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Incubation Time:0-48 h
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Result:Induced cell cycle arrest at G2/M phase.
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Cell Line:MDA-MB-468, MDA-MB-231 cells
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Concentration:0, 0.125, 0.25, 0.5 µM
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Incubation Time:24, 48 h
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Result:Induced apoptosis of cancer cells in a time-dependent and concentration-dependent manner with the expression of cleaved caspase-3 and cleaved PARP1 increased.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old female BALB/c nude mice[1]
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Dosage:30, 90 mg/kg
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Administration:P.o.; daily for 20 days
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Result:Remarkably inhibited the growth of tumor xenografts in a dose-dependent manner.
Chemical Information
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No. CAS 3040940-49-3
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Peso molecular 412.49
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Fòrmula C24H24N6O
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SMILES
CC(NC1=NC=CC(C2=CC3=C(C=C2)C(/C=C/C4=CC=C(CN(C)C)C=C4)=NN3)=N1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YLT-11 Related Classifications
HY-115589 Related Classifications
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