YUKA1
Based on 1 publication(s) in Google Scholar
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC50 = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.15%
- No. CAS: 708991-09-7
- Fòrmula: C13H16N4O2S
- Peso molecular:292.36
-
Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Epigenetics Compound Library
HY-L005
-
Histone Modification Research Compound Library
HY-L024
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Breast Cancer Compound Library
HY-L074
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Transcription Factor-Targeted Library
HY-L090
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Methylation Compound Library
HY-L203
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
Publications Citing Use of MedChemExpress (MCE) YUKA1
More
Actividad biológica
|
KDM5A 2.66 μM (IC50) |
KDM5C 7.12 μM (IC50) |
YUKA1 (50-100 μM, 48 h) increased H3K4me2 and H3K4me1 levels in HeLa and ZR-75-1 cells[1].
YUKA1 (25-100 μM, 3 days) inhibits proliferation in HeLa cells[1].
YUKA1 (50-100 μM, 2 weeks) reduces numbers of colonies in HeLa cells[1].
YUKA1 (100 μM, 35 days) reduces numbers of colonies companied with Trastuzumab (HY-P9907) in BT474 cells[1].
YUKA1 (100 μM, 35 days) reduces numbers of colonies companied with Gefitinib (HY-50895) in PC9 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HeLa cells
-
Concentration:50 and 100 μM
-
Incubation Time:48 h
-
Result:Increased H3K4me2 and H3K4me1 levels.
Chemical Information
-
No. CAS 708991-09-7
-
Appearance Solid
-
Peso molecular 292.36
-
Fòrmula C13H16N4O2S
-
Color White to off-white
-
SMILES
C=CCOC1=C(CNN2C(NN=C2)=S)C=CC=C1OC
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvente y solubilidad
DMSO : 100 mg/mL (342.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4204 mL | 17.1022 mL | 34.2044 mL | 85.5110 mL |
| 5 mM | 0.6841 mL | 3.4204 mL | 6.8409 mL | 17.1022 mL | |
| 10 mM | 0.3420 mL | 1.7102 mL | 3.4204 mL | 8.5511 mL | |
| 15 mM | 0.2280 mL | 1.1401 mL | 2.2803 mL | 5.7007 mL | |
| 20 mM | 0.1710 mL | 0.8551 mL | 1.7102 mL | 4.2756 mL | |
| 25 mM | 0.1368 mL | 0.6841 mL | 1.3682 mL | 3.4204 mL | |
| 30 mM | 0.1140 mL | 0.5701 mL | 1.1401 mL | 2.8504 mL | |
| 40 mM | 0.0855 mL | 0.4276 mL | 0.8551 mL | 2.1378 mL | |
| 50 mM | 0.0684 mL | 0.3420 mL | 0.6841 mL | 1.7102 mL | |
| 60 mM | 0.0570 mL | 0.2850 mL | 0.5701 mL | 1.4252 mL | |
| 80 mM | 0.0428 mL | 0.2138 mL | 0.4276 mL | 1.0689 mL | |
| 100 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8551 mL |
YUKA1 Related Classifications
HY-100764 Related Classifications
Powered by Bioz