Ap2m1 - adaptor related protein complex 2 subunit mu 1 Gene

Also Known as mu2; Ap50; Clapm1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 116563

Summary

Enables low-density lipoprotein particle receptor binding activity and signal sequence binding activity. Involved in positive regulation of endocytosis; protein-containing complex assembly; and vesicle-mediated transport in synapse. Located in terminal bouton. Part of AP-2 adaptor complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap2m1 Products (1)

mRNA	Protein	Name
NM_053837.2	NP_446289.1	AP-2 complex subunit mu

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables low-density lipoprotein particle receptor binding	IDA IDA: Inferred from direct assay	12121421	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9162036	RGD
enables signal sequence binding	IDA IDA: Inferred from direct assay	12121421	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	12105201	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	19762466	RGD
involved in postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	17289840	RGD
involved in postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	17289840	RGD
involved in postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	17289840	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	2870069	RGD
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	19321783	RGD
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	19321783	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of AP-2 adaptor complex	IDA IDA: Inferred from direct assay	12086608	RGD
is active in extrinsic component of presynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	8682861	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17289840	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17289840	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17289840	RGD
is active in synaptic vesicle	EXP EXP: Inferred from Experiment	33376223	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	33376223	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
AP-2 complex subunit mu	AP-2 mu chain adapter-related protein complex 2 mu subunit adapter-related protein complex 2 subunit mu adaptor protein complex AP-2 subunit mu adaptor-related protein complex 2 subunit mu adaptor-related protein complex 2, mu 1 subunit clathrin ass

Ap2m1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ap2m1	P84092	Ttgn1	Rattus norvegicus	P19814	Y2H	9341158
Intra	Ap2m1	P84092	Ttgn1	Rattus norvegicus	P19814	Fluorescence Spectr	9162036
Cross	Ap2m1	P84092	ITGA2	Homo sapiens	P17301	Pull Down	26779610
Cross	Ap2m1	P84092	ITGA2	Homo sapiens	P17301	ITC	26779610
Cross	Ap2m1	P84092	ITGA4	Homo sapiens	P13612	X-Ray Diffraction	26779610
Cross	Ap2m1	P84092	ITGA4	Homo sapiens	P13612	ITC	26779610

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161261	SARS-CoV-2-IN-81	Inhibitor	/	Unkown
HY-169405	AAK1/HDACs-IN-1	Inhibitor	/	Unkown
HY-RS00787	AP2M1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22390	Ap2m1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ap2m1	NCBI	NCBI:1173