Ccl4 - C-C motif chemokine ligand 4 Gene

Also Known as Scya4; Mip1-b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116637

Summary

Enables chemokine activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of tumor necrosis factor production; and positive regulation of vascular permeability. Predicted to be active in extracellular space. Biomarker of anti-basement membrane glomerulonephritis; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL4L2 (C-C motif chemokine ligand 4 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccl4 Products (1)

mRNA Protein Name
NM_053858.2 NP_446310.2 C-C motif chemokine 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
10679105 RGD
Biological Process GO Annotation Evidence References Source
involved in leukocyte chemotaxis IDA
IDA: Inferred from direct assay
10679105 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
10679105 RGD
involved in positive regulation of vascular permeability IDA
IDA: Inferred from direct assay
10679105 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-C motif chemokine 4

  • MIP-1-beta

  • chemokine (C-C motif) ligand 4

  • macrophage inflammatory protein 1-beta

  • small-inducible cytokine A4

Recombinant Ccl4 Proteins

Cat. No. Product Name Accession Purity
HY-P71899 CCL4 Protein, Rat P50230 (A24-N92) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-B0498 Bindarit Inhibitor 99.59% Phase 3
HY-152846 Flizasertib Inhibitor 99.9% Phase 2
HY-152293 EVT801 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0823 Lithospermic acid 99.56% Unkown
HY-N0373 Licochalcone B 99.91% Unkown
HY-N0330 Momordin Ic 99.78% Unkown
HY-163897 PROTAC NCOA4 degrader-1 Inhibitor 99.75% Unkown
HY-N5092 7-Methylcoumarin 99.93% Unkown
HY-145801 XT2 Inhibitor 99.60% Unkown
HY-N2358 Blumeatin 99.90% Unkown
HY-N2082 Isorhamnetin 3-O-galactoside Inhibitor 99.64% Unkown
HY-149202 UT-11 Inhibitor 98.25% Unkown
HY-N9173 Cupressuflavone 99.32% Unkown
HY-121944 Ricinine 99.81% Unkown
HY-N7327 Ochnaflavone Inhibitor 98.30% Unkown
HY-N7697B Chitobiose dihydrochloride 99.84% Unkown
HY-N8389 Globulol 99.74% Unkown
HY-133019 ATX inhibitor 5 Inhibitor 99.20% Unkown
HY-121271 Kadsurin 99.38% Unkown
HY-122951 Eburicoic acid Inhibitor 98.61% Unkown
HY-N2998 Ganoderenic acid A Inhibitor 97.93% Unkown
HY-N7697F Chitobiose / Unkown
HY-N15155 Vitexin 7-O-β-D-glucopyranoside 96.28% Unkown
HY-106417 Limazocic Inhibitor / Unkown
HY-120406 PLS-123 / Unkown
HY-168713 LZ-007 Agonist / Unkown
HY-170846 FGFRs-IN-1 Inhibitor / Unkown
HY-172087 VDR agonist 3 Agonist / Unkown
HY-172258 5-HT2B antagonist-2 Inhibitor / Unkown
HY-178015 THR-β agonist 11 Agonist / Unkown
HY-178328 VDR agonist 4 / Unkown
HY-179613 D-Leucine amide-CDDO-Me-HMP / Unkown
HY-180765 Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene Activator / Unkown
HY-182287 PRDX1-IN-4 / Unkown
HY-N0373R Licochalcone B (Standard) / Unkown
HY-N12016 Fulvotomentoside B / Unkown
HY-N3315 Massonianoside B / Unkown
HY-P11264 Cyclic peptide P1-1 / Unkown
HY-RS02102 CCL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02103 CCL4L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02104 CCL4L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121944S Ricinine-d3 / Unkown
HY-168629 FXR agonist 9 Inhibitor / Unkown
HY-174752 Human CCL4L1 mRNA / Unkown
HY-RS16594 Ccl4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23028 Ccl4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl4 NCBI NCBI:6351