HSPA12B - heat shock protein family A (Hsp70) member 12B Gene

Also Known as C20orf60

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116835

About HSPA12B

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,732,685-3,753,111 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 4 paralogues. Broad expression in fat (RPKM 15.5), spleen (RPKM 11.6) and 19 other tissues.

Summary

The protein encoded by this gene contains an atypical heat shock protein 70 (HSP70) ATPase domain and is therefore a distant member of the mammalian HSP70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

HSPA12B Products (3)

mRNA Protein Name
NM_001197327.2 NP_001184256.1 heat shock 70 kDa protein 12B isoform 2
NM_001318322.2 NP_001305251.1 heat shock 70 kDa protein 12B isoform 3
NM_052970.5 NP_443202.3 heat shock 70 kDa protein 12B isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heat shock 70 kDa protein 12B

HSPA12B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSPA12B Q96MM6 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
HSPA12B Q96MM6 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
HSPA12B Q96MM6 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
HSPA12B Q96MM6 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
HSPA12B Q96MM6 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
HSPA12B Q96MM6 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
HSPA12B Q96MM6 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
HSPA12B Q96MM6 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
HSPA12B Q96MM6 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
HSPA12B Q96MM6 HSPA12A Homo sapiens O43301
Y2H Array
32296183
Intra
HSPA12B Q96MM6 HSPA12A Homo sapiens O43301
Y2H Prey Pooling
32296183
Intra
HSPA12B Q96MM6 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
HSPA12B Q96MM6 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
HSPA12B Q96MM6 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
HSPA12B Q96MM6 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
HSPA12B Q96MM6 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Intra
HSPA12B Q96MM6 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra
HSPA12B Q96MM6 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
HSPA12B Q96MM6 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
HSPA12B Q96MM6 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
HSPA12B Q96MM6 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
HSPA12B Q96MM6 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06421 HSPA12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HSPA12B VGNC VGNC:84531
Felis catus HSPA12B VGNC VGNC:80114
Mus musculus HSPA12B MGD MGI:1919880
Canis familiaris HSPA12B VGNC VGNC:53543
Rattus norvegicus HSPA12B RGD RGD:1312004
Others HSPA12B NCBI