Cd14 - CD14 antigen Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12475

Summary

This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and Fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]

Cd14 Products (1)

mRNA	Protein	Name
NM_009841.4	NP_033971.1	monocyte differentiation antigen CD14 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	8612135	MGI
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	22078883	MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24380872	MGI
involved in positive regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	24380872	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	8612135	MGI
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	22078883	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	24380872	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	22078883	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
involved in response to bacterium	IMP IMP: Inferred from mutant phenotype	8612135	MGI
involved in response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	15493995	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8612135	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15493995	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
monocyte differentiation antigen CD14	myeloid cell-specific leucine-rich glycoprotein

Recombinant Cd14 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P73531	CD14 Protein, Mouse (HEK293, His)	P10810/NP_033971.1 (S16-P345)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75444	CD14 Protein, Mouse (HEK293, His-Fc)	P10810/NP_033971.1 (S16-P345)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-N9965	2'-Fucosyllactose	Inhibitor	99.97%	Phase 2
HY-101132	VB-201		/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99008	Atibuclimab	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-W251428	Phosphatidylglycerols (egg) sodium salt		99.53%	Unkown
HY-135750	VAF347	Agonist	99.75%	Unkown
HY-W040255	1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine		99.9%	Unkown
HY-182019	HDAC11-IN-5		98.25%	Unkown
HY-161901	BC-1293	Inhibitor	98.40%	Unkown
HY-178049A	UM-259 hydrochloride	Inhibitor	/	Unkown
HY-101132A	(Rac)-VB-201	Inhibitor	/	Unkown
HY-129684	IAXO-101 iodide	Inhibitor	/	Unkown
HY-151399	Antimicrobial agent-5	Inhibitor	/	Unkown
HY-169067	10-Methoxy-canthin-6-one		98.71%	Unkown
HY-D3334	PE-CF594		/	Unkown
HY-RS02189	CD14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09127	NDUFA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16726	Cd14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23162	Cd14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P991004	Itanistomig		95.84%	Unkown
HY-P992435	OX118	Inhibitor	/	Unkown
HY-P991845	Anti-CD14 Antibody (UCHM-1)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd14	NCBI	NCBI:929