Clk2 - CDC-like kinase 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12748

Summary

Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in negative regulation of gluconeogenesis and protein autophosphorylation. Acts upstream of or within peptidyl-tyrosine phosphorylation and response to retinoic acid. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; liver; retina; and thyroid gland. Orthologous to human CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Clk2 Products (2)

mRNA Protein Name
NM_001163432.2 NP_001156904.1 dual specificity protein kinase CLK2 isoform 2
NM_007712.4 NP_031738.2 dual specificity protein kinase CLK2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9307018 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
9307018 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
20074525 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
9307018 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
9307018 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
9852100 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
20074525 MGI
acts upstream of or within response to retinoic acid IDA
IDA: Inferred from direct assay
18400104 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9307018 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein kinase CLK2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-144875 Rogocekib Inhibitor 98.15% Phase 2
HY-137443 Ipivivint Inhibitor 99.95% Phase 1

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115470 CLK-IN-T3 Inhibitor 99.78% Unkown
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-112296 T025 99.64% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-108709 CC-671 Inhibitor 99.06% Unkown
HY-155723 Leucettinib-92 Inhibitor 98.54% Unkown
HY-153708 SGC-CLK-1 Inhibitor 99.12% Unkown
HY-123600 SRI-29329 Inhibitor 99.14% Unkown
HY-125290 MU1210 Inhibitor 99.50% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-132175 CK2 inhibitor 2 Inhibitor 98.51% Unkown
HY-149262 CLK1-IN-3 98.54% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-131978 DB18 Inhibitor 99.15% Unkown
HY-113825 CLK1/2-IN-1 Inhibitor 99.87% Unkown
HY-P10042A S6K Substrate acetate Substrate 98.19% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-P10042 S6K Substrate Substrate / Unkown
HY-113670 CLK1/2-IN-2 Inhibitor 99.31% Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-123853 CAM4066 Inhibitor / Unkown
HY-125201 Indazole 1 Inhibitor / Unkown
HY-125202 KuWal151 Inhibitor / Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-162398 LQ23 Inhibitor / Unkown
HY-168209 LBM22 / Unkown
HY-173510 CLK2/3-IN-1 Inhibitor / Unkown
HY-176884 CDD-2110 Inhibitor / Unkown
HY-176885 CDD-2211 Inhibitor / Unkown
HY-176885A CDD-2212 Inhibitor / Unkown
HY-182323 SGK1-IN-7 Inhibitor / Unkown
HY-183831 GPS167 / Unkown
HY-RS02817 CLK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14360 TELO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16769 Clk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23209 Clk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clk2 NCBI NCBI:1196